Pain

Question 1

Discord between GCaMP and electrophysiological studies may arise from invasiveness of electrophysiology and trauma of dissociation

Answer 1

Smith, 2018

Question 2

Cloning of capsaicin receptor via calcium influx

Answer 2

Caterina et al, 1997

Question 3

TRMP3, TRPV1, TRPA1 involved in noxious heat sensing

Answer 3

Vadewauw et al, 2018

Question 4

TRPM8 knockout mice = diminished cold response, but avoid surfaces <10°C

Answer 4

Bautista et al, 2007

Question 5

TRPA1-dependent cold-induced nociceptive behaviour in mice

Answer 5

Karashima et al, 2009

Question 6

Piezo1 required for mechanical currents; piezo2 knockdown reduces RA currents

Answer 6

Coste et al, 2010

Question 7

Loss of piezo2 = impaired noxious mechanical response; optogenetic activation = nociception

Answer 7

Murthy et al, 2018

Question 8

Evolutionary pressure for more profound acid-induced inhibition of Nav1.7 in naked mole rats

Answer 8

Smith et al, 2011

Question 9

Mambalgin abolishes pain via inhibition of ASICs in central/peripheral neurones

Answer 9

Diochot et al, 2012

Question 10

Neuropathic pain initiated by HCN2-driven AP firing in Nav1.8-expressing nociceptors

Answer 10

Emery et al, 2011

Question 11

Epac1-Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain

Answer 11

Eijelkamp et al, 2013

Question 12

Epac inhibitor reverses mechanical allodynia and loss of intraepidermal fibres in model of cheotherapy-induced peripheral neuropathy

Answer 12

Singhmar et al, 2018

Question 13

Requirement for NaV 1.7 in regulating somatic (noxious heat pain threshold) but not in visceral pain signalling

Answer 13

Hockley et al, 2017

Question 14

Engineered glutamate-gated chloride channel to silence sensory neurones and treat neuropathic pain

Answer 14

Weir et al, 2017

Question 15

Cobra neurotoxin produces central analgesic and hyperalgesic actions via adenosine receptors

Answer 15

Chuang et al, 2017

Question 16

Ipsilateral and contralateral localised vibratory stimulation modulated pain-related sensory thresholds

Answer 16

Doi et al, 2018

Question 17

NMDA receptor activation underlies loss of spinal dorsal horn neurones and transition to persistent pain after peripheral nerve injury

Answer 17

Inquimbert et al, 2018

Question 18

Temperature triggering behavioural and TRPA1 responses lower for shade-dwelling lizards

Answer 18

Akashi et al, 2018

Question 19

Density of TRPA1 regulated by TRPV1; heteromerisation may change roperties

Answer 19

Akopian, 2011

Question 20

TRPA1/V1 complex co-immunoprecipitated and interaction confirmed by TIRF FRET

Answer 20

Staruschenko et al, 2010

Question 21

Cannabinoids desensitise capsiaicin and mustard oil responses in sensory neurones via TRPA1 activation

Answer 21

Akopian et al, 2008

Question 22

Sporadic onset of erythermalgia (Nav1.7)

Answer 22

Rush et al, 2006

Question 23

Nav1.8 in grasshopper mice defends against bark scorpion toxin

Answer 23

Rowe et al, 2013

Question 24

Hypofunctional TrkA accounts for absence of pain sensitisation in naked mole rat

Answer 24

Omerbasic et al, 2016