Lecture 5 Flashcards
What is the primary structure?
Protein sequence
What is the secondary structure?
Mainchain H bonds
alpha helices, beta sheets
What is the super secondary structure?
Combining secondary
- aa, BaB (parallel sheets), BB antiparallel sheets
What is the tertiary structure?
Folds
- aaaa, BaBaB, BBBB
Most common motif?
All alpha proteins
Provide an example of
1) all alpha
2) all beta
3) a/B
4) a + B
1) all alpha
2) all beta
3) a/B
4) a + B
Provide an example of
1) Multidomain proteins
2) Membrane proteins
3) Small proteins
4) Coiled coils
1) Multidomain proteins
2) Membrane proteins
3) Small proteins
4) Coiled coils
Another name for supersecondary structure
Motifs
Two examples of alpha motifs?
- EF hands
2. helix turn helix
Three examples of beta motifs?
- Beta-hairpin (2 stranded antiparallel sheet)
- B-meander
- B propeller structures (antiparallel, edge strands)
- B-barrel/B-sandwich structures (antiparallel, no edge strands, is a true barrel B-sheet that closes upon itself) - Greek key
- 4 antiparallel beta sheets (no H bonds)
Draw greek key
N/A
Two examples of A/B motifs?
- Open-twisted (singly wound)
- parallel beta strands, helices outside - Closed (doubly wound) α/β
- parallel beta strands, helices outside
Example of 7 all alpha protein folds?
- 4 helix bundle
- 7 TM segment helical bundle
- TetratricoPeptide Repeats (TPRs) (ankyrin-like repeats)
- Coiled coils
- Globin
- Helix-turn-helix
- EF hands
Example of 4 all beta protein folds?
- B-barrels
- B-sandwiches
- 2 sheets, antiparallel strands - B-propellers
- B-helix
- parallel b-sheets, 2 or 3 faces (sheets)
5.
Example of 4 a/B protein folds?
- a/B repeat
- α/β-closed, singly wound (TIM barrel)
- α/β open-twisted sheet, doubly wound
- a/B horse shoe fold
