Thrombin Inhibitor Flashcards
1
Q
What are examples of thrombin inhibitors?
A
Dabigatran
2
Q
What are indications for the use of thrombin inhibitors?
A
- Prophylaxis of venous thromboembolism following surgery
- Prophylaxis and treatment of DVT and PE
- Prophylaxis of stroke and systemic embolism in non-valvular AF
3
Q
What are contraindications of thrombin inhibitors?
A
- Active bleeding
- Oesophageal varices
- Malignant neoplasms
- Recent brain/spine surgery
- Recent intracranial haemorrhage
- Severe liver disease
- Pregnancy and breastfeeding
4
Q
What is the mechanism of action of dabigatran?
A
Dabigatran is a competitive direct inhibitor of thrombin, thereby inhibiting the coagulation cascade as thrombin is the enzyme required to convert fibrinogen to fibrin
5
Q
What are adverse reactions of thrombin inhibitors?
A
- Abdominal Pain
- Diarrhoea
- Dyspepsia
- Nausea
- Haemorrhage
