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Cell Bio Exam > Drugs to know > Flashcards

Drugs to know Flashcards

1
Q

THC/CBD (Cannabis)

A
  • Molecule type: Cannabinoid
  • Receptor: Cannabinoid receptors: CB1, CB2
  • Receptor type: GPCR
  • Endogenous ligand: Arachodonylglycerol (2-AG), Arachidonylethanolamine (AEA)
  • Drug action: Receptor agonist
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2
Q

Muscarine

A
  • Molecule type: Alkaloid
  • Receptor: Muscarinergic Acetylcholine (Ach) receptor
  • Receptor type: GPCR
  • Endogenous ligand: Acetylcholine (Ach)
  • Drug action: receptor agonist
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3
Q

Atropine

A
  • Molecule type: Alkaloid
  • Receptor: Muscarinergic Ach receptor
  • Receptor Type: GPCR
  • Endogenous ligand: Ach
  • Drug action: Receptor antagonist
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4
Q

Caffeine

A
  • Molecule type: Alkaloid
  • Receptor: Adenosine receptor
  • Receptor type: GPCR
  • Endogenous Ligand: Adenosine
  • Drug Action: Receptor antagonist
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5
Q

Cocaine, Amphetamines

A
  • Molecule type: Alkaloid
  • Receptor: Dopamine re-uptake transporter (DAT)
  • Receptor Type: SLC carrier transporter
  • Endogenous ligand: Dopamine
  • Drug action: Blocks dopamine re-uptake transporters
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6
Q

Morphine

A
  • Molecule type: Alkaloid
  • Receptor: Opiate receptor
  • Receptor type: GPCR
  • EndogenousLigand: Enkephalins, β-endorphine
  • Drug action: μ‐Opiate receptor agonist
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7
Q

Salvinorin A (Salvia divinorum)

A
  • Molecule type: Diterpene
  • Receptor: Opiate receptor
  • Receptor Type: GPCR
  • Endogenous ligands: Enkephalins, β-endorphine
  • Drug Action: κ‐Opiate receptor agonist
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8
Q

Mescalin, Psilobin

A
  • Molecule type: Alkaloid
  • Receptor: 5HT2A-Receptor
  • Receptor type: GPCR
  • Endogenous ligand: Seratonin
  • Drug action: Receptor agonists
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9
Q

Nicotine

A
  • Molecule type: Alkaloid
  • Receptor: Nicotinic Ach receptor (Channel)
  • Receptor type: Cation Ion channel
  • Chemical ligand: Ach
  • Drug Action: Agonist
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10
Q

Curare

A
  • Molecule type: alkaloid
  • Receptor: Nicotinic Ach receptor (channel)
  • Receptor type: Cation Ion channel
  • Chemical ligand: Ach
  • Drug Action: Antagonist
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11
Q

Muscimol

A
  • Molecule type: Alkaloid
  • Receptor: GABA-receptor (channel)
  • Receptor type: Ion Channel
  • Endogenous ligand: γ‐aminobutyric acid (GABA)
  • Drug Action: Agonist
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12
Q

Thujone

A
  • Molecule type: Monoterpene
  • Receptor: GABA-receptor (channel)
  • Receptor type: Cl- Ion Channel
  • Endogenous ligand: γ‐aminobutyric acid (GABA)
  • Drug Action: Antagonist
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13
Q

Strychnine

A
  • Molecule type: Alkaloid
  • Receptor: Glycine receptor (channel)
  • Receptor type: Cl- Ion channel
  • Endogenous ligand: Glycine
  • Drug action: Antagonist
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14
Q

Ibotenic acid

A
  • Molecule type: Alkaloid
  • Receptor: Glutamate receptors (channel)
  • Receptor type: Ligand gated Na+/Ca2+ Ion channel
  • Che ligand: glutamate, Glutamate/glycine NMDA
  • Drug Action: Agonist
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15
Q

Capsaicin

A
  • Molecule type: Alkaloid
  • Receptor: TRPV1
  • Receptor Type: Cation Ion channel
  • Endogenous ligand: Voltage “transient receptor potential” heat
  • Drug action: Simulates heat (activated channel)
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16
Q

Menthol

A
  • Molecule Type: Monoterpene
  • Receptor: TRPM8
  • Receptor type: Cation Ion channel
  • Endogenous ligand: Voltage “transient receptor potential” Cold
  • Drug Action: Shifts activation threshold to less cold temperatures via allosteric modulation
17
Q

Aconitine

A
  • Molecule type: Alkaloid
  • Ion channel: Voltage gated Na+
  • Drug action: Stops channels from closing
18
Q

Digitoxin

A
  • Molecule type: Phytosteroid
  • Ion channel: Voltage gated Na+/K+ - pump
  • Drug Action: inhibition of Na+/K+-ATPase
19
Q

Ryanodine

A
  • Molecule type: Diterpene
  • receptor: Ryanodine receptor
  • Ions: Ca2+ channel
  • Drug Action: locks receptor in half open state, causing release of calcium stores
20
Q

Agatoxin (animal)

A
  • Channel: P/Q type channel
  • Ion: Ca2+
  • Drug action: Blocks channel
21
Q

Conotoxin (animal)

A
  • Channel: N-type channel
  • Ion: Ca2+
  • Drug action: inhibits channels
22
Q

Tarantula venom

A
  • Channel: R-type
  • Ion: Ca2+
  • Drug action: Blocks channel

Cell Bio Exam (17 decks)

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