Pharmacology of Adrenergic agonists and antagonists Flashcards
T/F: The adrenergic Nervous system relates to the fight or flight system of the autonomic nervous system
True
What type of receptors are the alpha and beta receptors of the adrenergic nervous system
G-coupled protein receptors
In a synapse where are the alpha 1 receptors usually located
Post synaptic membrane of effector organs
What does alpha-1 receptor activation do
contraction throughout the body (mydriasis, vasoconstriction, goosebumps)
What does beta-2 receptor activation do
relaxtion throughout the body ( vasodilation, bronchodilation)
What does beta-1 receptor activation do
increase heart rate, increased force of contraction, increased conduction velocity, renin release
What does alpha-2 receptor activation do
Inhibit norepinephrine release
What are two consequnces of using drug agonists
Desentization and Denervation
What is denervation supersensitivity
When loss of nerve occurs the effector muscle grows a much more sensitive to the neurotransmitter
What is the main neurotransmitter of the sympathetic nervous system
Norepinephrine
What are the classification for adrenergic agonists based on their structure
catecholamine and non-catecholamines
What are the classifications for adrenergic agonists based on their action
direct-acting, indirect-acting, mixed-acting
What enzymes metabolize circulating catecholamines as well as ones in the brain
COMT and MAO
T/f: Catecholamines can be given orally
False: Catecholamines are dosed IV, IM, topically, and aerosol
What property of non-catecholamines protects them from MAO metabolism
substitution on the alpha carbon
