Autonomic Nervous System Flashcards
Adrenergic
a nerve ending that releases norepinephrine as the primary transmitter
a synapse in which norepinephrine is the primary transmitter
Cholinergic
a nerve ending that releases acetylcholine
a synapse in which the primary transmitter is acetycholine
Sympathetic
motor fibers originate in thoracolumbar spinal cord
fight or flight
Parasympathetic
motor fibers originate in cranial nerves and sacral spinal cord
rest and digest
PNS: neurotransmitters
acetylcholine
SNS: neurotransmitters
norepinephrine
M2 Receptors
cholinoceptors
location: heart
function:
- dec cAMP
- activates K channels
M3 Receptors
cholinoceptors
location: effector cells (smooth muscle, glands, endothelium)
function:
inc IP3, DAG cascade
Alpha 1 Receptors
adrenoceptors
location:
smooth muscle, glands
function: -inc Ca2 -causes contraction -secretion (causes vasoconstriction)
Alpha 2 Receptors
adrenoceptors
location:
nerve endings, some smooth muscle
function:
-dec transmitter release
-causes contraction
(inhibits/monitors A1)
Beta 1 Receptors
adrenoceptors
location: cardiac muscle, juxtaglomerular aparatus
function: -inc HR -inc force -inc renin release (inc stroke volume, inc conductivity)
Beta 2 Receptors
adrenoceptors
location: lungs, smooth muscle, liver, heart
function: -relax smooth muscle -inc glycogenolysis -inc HR, force (bronchodilation)
Beta 3 Receptors
adrenoceptors
location: adipose cells
function:
- inc lipolysis
Dopamine 1 Receptors
adrenoceptors
location: smooth muscle (kidneys)
function:
-relax renal vascular smooth muscle
Characteristics of Neurotransmitters
norepinephrine can have reuptake
acetycholine does not get recycled
