413 Drugs

Question 1

Trogarzo

Answer 1

Used to bind to CD4 and prevent HIV from binding to CD4+ which prevents CD8 from breaking down and killing the CD4.

Killing the CD4 leads to AIDs

Question 2

Abatacept

Answer 2

Binds to both CD80 and CD86, which blocks T-cell activation via costimulation blockage CTLA4Ig

Used in RA

Question 3

Cyclosporine and Tacrolimus

Answer 3

Inhibit calcineurin, which blocks T-cell activation by inhibiting activation of NFAT

Immunosuppressive drug

Question 4

Murononab

Answer 4

Blocks TCR signaling by binding to CD3 and depletes T-cells

Used as an immosuppressive drug

Question 5

What do Tregs produce

Answer 5

They are made in the thymus and they secret inhibitory cytokines IL-10 and tissue factor beta (TGF-B)

This blocks the activation and effector functions of self-reactive and pathogenic lymphocytes in the periphery

Also will block activation of macrophages

Lacking this leads to autoimmune diseases