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Pharm Block 1 > Cholinergic & Anticholinergic > Flashcards

Cholinergic & Anticholinergic Flashcards

1
Q

located in the CNS and gastric parietal cells

A

M1

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2
Q

increase gastric acid - HCL

CNS excitation

A

M1

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3
Q

M1 and M3 have what mechanism

A

Gq - IP3, DAG - increase in Ca2+ concentration

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4
Q

M2 mechanism

A

Gi - inhibits adenyl cyclase, decrease cAMP and opening of K+ channel

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5
Q

located in heart - SA and AV node, presynaptic terminal

A

M2

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6
Q

decrease rate of impulse generation, velocity of conduction decreased, contractility decreased

A

M2

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7
Q

located in smooth muscles in exocrine glands, GIT, genitourinary system, constrictor pupilae, glands

A

M3

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8
Q

increase in exocrine secretion, smooth muscle contraction, miosis

A

M3

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9
Q

binds to activate endothelial NO synthase, vasodilation due to release fo EDRF - increases cGMP to dephosphorylate myosin LC

A

acetylcholine

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10
Q

M3 stimulation increases bowel movements and bladder contractions - emptying

A

bethanechol

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11
Q

treats paralytic ileus - reduced bowel movements; urinary retention

A

bethanechol

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12
Q

SE: CNS stimulation, miosis, bradycardia, bronchoconstrictor, accommodation of near vision, abdominal cramps, flushing, salivation

A

bethanechol

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13
Q

Contraindications: asthma, peptic ulcer, MI

A

bethanechol

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14
Q

increases aqueous humor outflow; increases peristalsis and treats glaucoma

A

carbachol

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15
Q

stimulates bronchial construction and used in diagnosis of asthma

A

methacholine

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16
Q

M3 stimulation - increase salivation, lacrimation, increase aqueous humor outflow (glaucoma); ciliary muscle - contraction

A

pilocarpine

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17
Q

used to treat xerostomia, stimulates salivary secretion in post op, open angle glaucoma, iris-cyclitis adhesions

A

pilocarpine

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18
Q

selective muscarinic: found in mushrooms, responsible for cholinergic symptoms in mushroom poisoning

A

muscarine

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19
Q

neurally occurring tertiary amine that is well absorbed and crosses BBB

A

nicotine

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20
Q

synthetic partial agonist at alpha 4 beta 2 subtype nicotinic receptors used in the treatment of smoking cessation

A

varenicline

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21
Q

stimulates M3 (salivary glands) - increase secretion; used to treat xerostomia in chemo patients and sjogren syndrome

A

cevimeline

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22
Q

M3 - enters CNS; penetrates cornea

Treats: open angle glaucoma and atropine overdose antidote (IV-Belladonna poisoning)

A

physiostigmine

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23
Q

shortest duration of action

Dx: of MG and differentiate between Myasthenic and Cholinergic crisis - Tension test

A

edrophonium

24
Q

crisis in which patient gets better

A

Myasthenci crisis

25
Q

crisis in which patient gets worse because their already on AchE inhibitors

A

Cholinergic crisis

26
Q

used in acute myasthenia gravis cases; atony of bladder, paralytic ileus, reversible skeletal muscle blocker
dont use in glaucoma

A

neostigmine

27
Q

used in treatment of long term MG

DOA: 6 hrs

A

pyridostigmine

28
Q

increase CNS Ach

used to treat Alzheimers

A

Danoprezil
rivastigmine
galantine
tacrine

29
Q

increase aqueous humor outflow
used to treat glaucoma
irreversible Ache inhibitor

A

ecothoiophate

30
Q

irreversible Ache inhibitors

organophosphates

A 
malathion
parathion
sarin
tabun
soman
voltile X
31
Q

Treatments of OP poisoning

A

atropine - muscarinic symtoms

pralidoxime (2-PAM) - antidote AchE reactivator for nicotinic symptoms

32
Q

DUMBBELLS (OP SE)

A 
diarrhea
urination
miosis
bradycardia
bronchospasm
emesis
lacrimation
lethargy
salivation
33
Q

used to control head lice

A

carbaryl

34
Q

inhibits choline transporter

A

hemicholinium

35
Q

inhibits Ach from entering into vesicle

A

vesamicol

36
Q

inhibits SNAPS

A

botulinum

37
Q

blocks M2; M3 and M1 anti motion sickness

A

atropine

38
Q

used in treatment for OP poisoning, cholinergic poisoning, mushroom poisoning, 2nd degree HB and bradycardia

A

atropine

39
Q

M1 and M3 blocker; absorbed through skin

A

scopolamine

40
Q

used in motion sickness and nausea associated with opioid analgesia, and to reverse central Nn receptors in cholinergic poisoning

A

scopolamine

41
Q

decreases secretion, relax smooth muscle of bronchi and bronchioles, decrease airway resistance, bronchodilation

A

ipratropium

tiotropium

42
Q

used to treat exercise induce bronchospasm, chronic bronchitis, asthma, COPD

A

ipratropium

tiotropium

43
Q

produce mydriasis

A

cyclopentolate
tropicamide
homatropine

44
Q

used in measurement of refractory error

A

tropicamide

45
Q

ophthalmic exam

A

cyclopentolate

46
Q

break adhesion iris and anterior surface of lens

A

homatropine

47
Q

decrease secretions of GIT, relaxation of smooth muscle, decreased GI motility and peristalsis

A

dicylomine
flavoxate
glycopyrrolate

48
Q

used in irritable bowel syndrome

A

dicylomine

49
Q

used in pre op medication to reduce salivary and respiratory secretions and in post op in combo with neostigmine to reverse effects of non depolarizing skeletal muscle relaxants

A

glycopyrrolate

50
Q

blocks M3 helps in urine retention in adults and children

A

oxybutinin
tolterodine
derifenacin

51
Q

used in antispasmodic effects seen in overreactive bladder and in urinary incontinence; detrusor hyper reflex; enuresis

A

oxybutinin
tolterodine
derifenacin

52
Q

decrease secretion of GIT, relax smooth muscle of GIT, decrease GI motility and peristalsis

A

pirenzepine

53
Q

treats peptic ulcers

A

pirenzepine

54
Q

work centrally in the brain
used in Parkinson’s dz - helps decrease salivation, spasticity, and tremors;
treats drug induced extra pyramidal reactions

A

trihexyphenidyl
benztropine
biperiden

55
Q

treatment for anticholinergic overdose

A

physostigmine

56
Q

abolish baroreceptor reflex HR change; prevents PANS and SANS stimulation

A

mecamylamjne
hexamethonium
trimethoprim

Pharm Block 1 (5 decks)

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