REVIEW 4 (Pulm) Flashcards
Deletions in the _________ of Chromosome _______ are frequently found in all types of lung cancers
Deletions in the short arm of chromosome 3 (3p)
Which oncogenes are associated with lung cancer?
K-ras oncogenes
Myc oncogene
What 2 tumor suppressor genes are associated with lung cancer
- Mutations in the p53 gene (50% of Small cell carcinomas and 50% of Non-small cell carcinomas)
- Retinoblastoma gene (Rb) mutations (>80% of small cell carcinomas, 25% Non-small cell Carcinomas)
Which lung carcinoma is a distinctive subtype of adenocarcinoma that grows along preexisting alveolar walls?
Bronchioloalveolar Carcinoma
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/438/a_image_thumb.png?1550694022)
Which lung carcinoma accounts for 1-5 % of all invasive lung tumors?
Bronchioloalveolar carcinoma (BAC)
Which Lung carcinoma?
Copious mucin in the sputum is a distinctive sign
Bronchioloalveolar carcinoma (BAC)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/440/a_image_thumb.png?1550694245)
Which lung cancer?
Grossly:
- may appear as a single peripheral nodule or coin lesion (50%)
- multiple nodules or a diffuse infiltrate indisting-uishible from a lobar pneumonia.
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/441/q_image_thumb.png?1550694233)
Bronchioloalveolar carcinoma (BAC)
Which lung cancer?
2 major histologic patterns:
- 2/3 are nonmucinous
- 1/3 are mucinous tumors featuring increased amounts of goblet cells.
Bronchioloalveolar carcinoma (BAC)
Prognosis of which lung cancer?
- tumor limited to the lung (Stage I), detected as a solitary coin lesion= GOOD prognosis
- those w/ multiple nodules or diffuse lung involvement= POORER outcome
Bronchioloalveolar carcinoma (BAC)
Which lung carcinomas have the strongest association with cigarette smoking?
Squamous cell and small cell carcinomas
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Which lung carcinoma accounts for 30% of all invasive lung cancers in the U.S. (about equal to adenocarcinomas) and is always associated with cigarette smoking.
Squamous cell carcinoma
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/445/a_image_thumb.png?1550695052)
Which lung carcinoma?
Most arise in the central portion of the lung, although 10% can arise from the periphery.
Squamous cell carcinoma
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/446/a_image_thumb.png?1550695028)
Which lung carcinoma?
Grossly: firm, gray-white ulcerative masses which extend through the bronchial wall into the adjacent parenchyma.
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/447/q_image_thumb.png?1550695003)
Squamous cell carcinomas
Which lung carcinoma?
diagnosis may be made by cytology from bronchial washings or bronchial brushings during bronchoscopy. (central location
Squamous cell carcinoma
![](https://s3.amazonaws.com/brainscape-prod/system/cm/268/543/448/a_image_thumb.png?1550695193)
Are most Squamous cell carcinoma lung cancers invasive at diagnosis?
–>Resection specimens of these tumors reveal carcinoma in-situ in only one-third of cases, whereas the rest reveal varying degrees of invasion.
Squamous cell carcinoma