Antivirals Flashcards
Recall the type of genome in HIV
Single positive sense strand RNA (it is a retrovirus)
Recall the type of genome in hepatitis B
dsDNA
Recall the type of genome in hepatitis C
ssRNA
Recall the type of genome in HSV
DNA
Recall the type of genome in influenza
RNA
Which serotypes of hepatitis carry risk of chronic infection, and what are the consequences of this?
Hep B and C
Liver cirrhosis, hepatocarcinoma
For which hepatitis vaccine is there a vaccine available?
Hep B
Summarise the life cycle of HIV, naming relevant molecules and proteins
- GP120 binds CD4/CCR5/CXCR4
- Virus enters via GP41
- Genome replicated in cytoplasm via RT
- DNA integrated into host genome by integrase
- Host cell machinery produces viral proteins, via cleavage of Gag precursor by HIV protease
- Viral assembly
Recall the disease state related to HSV1 and 2
HSV1 = cold sores HSV2 = genital herpes
Summarise the escape of the influeza virus from each host cell
Uses neuraminidase to cleave sialic acid in membrane
Recall 2 drugs that inhibit HIV attachment and entry and their MOA
Enfuvirtide (binds GP41)
Maravirov (blocks CCR5)
Recall 3 classes of drug that inhibit HIV genome replication, and give an example of a drug within each
Nucleoside RT inhibitors: zidovudine
Nucleotide RT inhibitors: tenofovir
Non-nucleoside RT inhibitors: efavirenz
Recall an example of a drug that inhibits integration of HIV genetic material into the host genome, and its MOA
Raltegravir
Integrase inhibitor
Recall the MOA of saquinivir as an antiviral, and what it is coadministered with
HIV protease inhibitor
Coadministered with ritonavir to slow FPM of saquinivir
Which antiviral drug is used for HSV and what is its MOA
Acyclovir
Nucleoside analogues
