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Pharmocology > Cardiovascular Pharm > Flashcards

Cardiovascular Pharm Flashcards

1
Q

What is an arrhythmia?

A

Any deviation from formal rhythm of heart

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2
Q

What is an Antiarrythimics?

A

Used for treatment and prevention of disturbances of cardiac rhythm.

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3
Q

What are Class I, II, III, and IV antiarrytmic drugs?

A

I: Na+ channel blockers.
II: beta-adrenergic receptor blockers.
III: K+ channel blockers
IV: Ca++ cannel blockers.

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4
Q

What are the 3 subtypes of Class I antiarrythmic drugs and their mechanism?

A

IA: Moderate Na+ Channel Block with prolinged repolarization.
IB: Mild Na+ blocker with shortened repolarization.
IC: Marked Na+ channel blocker.

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5
Q

What are examples of IA drugs?

A

Quinidine, Procainamide.

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6
Q

What are examples of IB drugs?

A

Lidocaine.

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7
Q

What are examples of IC drugs?

A

Flecainide, Propafenone.

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8
Q

What do each of the subclass type I do?

A

IA: Reduces automaticity, decreases conductive velocity, increase refractory period.
IB: Reduces automaticity at abnormal pacemakers.
IC: Reduces automaticity, decreases conductive velocity.

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9
Q

What do Class II antiarrythmic drugs do? Example drugs?

A

Block sympathetic stimulation of heart. Propranolol, Esmolol.

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10
Q

What do class III antiarrythmic drugs do? Example Drugs?

A

Reduces automaticity. Amiodarone, Dronedarone and Satalol.

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11
Q

What do Class IV antiarrythmic drugs do? Example drugs?

A

Treats hypertension, angina, and atrial arrythmias. Verapamil, Diltiazem.

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12
Q

What do Positive ionotorpic, positive chronotropic, and positive dromotropic drugs do?

A
  1. Ionotropic: Increase the force of myocardial contraction.
  2. Chronotropic: Increase heart rate.
  3. Dromotropic: Accelerate cardiac conduction.
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13
Q

What do Cardiac Glycosides do? Drug Examples?

A

Treats congestive heart failure by increaseing strength of myocardial contraction and slows ventricular rate. Examples are Digoxin and Digitalis.

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14
Q

What do antianginal drugs do? Mechanism? Drug examples?

A

Help with pain from hypoxic heart tissue. Reduce carida rate, cardiac force, peripheral resistance, and dilate coronary arteries.

  • Calcium channel blockers
  • Beta blockers
  • Vasodilators
  • Antiplalet drugs
  • Ranolazine
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15
Q

What do statins do? Fibrates?

A

Lower lipids in the body.

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16
Q

What does nicotinic acid do?

A

Inhibits VLDL secretion.

Pharmocology (8 decks)

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