Pharmacology

Question 1

What is the mean inhibitory concentration?

Answer 1

concentration of drug needed to kill 99.9% of organisms during 18-24hours

Question 2

What are the characteristics of aminoglycosides?

Answer 2

given with high concentration then are cleared quickly

Question 3

What are the characteristics of betalactams?

Answer 3

have a longer lasting MIC so can be givne multiple times a day

Question 4

What must be cleared before antibiotics can be affective?

Answer 4

pus

Question 5

Where is it hard for antibiotics to get into?

Answer 5

areas with tight junctions - CNS, eyes, prostate

Question 6

What are the ways that bacteria can become resistant??

Answer 6

active efflux - pushes antibiotic out of the cell
target replication - makes antibiotic less effective
modified drug target
decreased permeability - alters its cell wall structure so decreased penetration
drug interacting enzymes - bacteria produce inactivating enzymes