Bleeding in Early Pregnancy Flashcards

1
Q

What are the seven variations of pregnancy loss

A

1) Threatened miscarriage 2) Inevitable miscarriage 3) Incomplete Miscarriage 4) Complete miscarriage 5) Missed miscarriage 6) Ectopic Pregnancy 7) Molar pregnancy

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2
Q

How common are miscarriages?

How many miscarriages occur in the first trimester?

A

Common with a rate of 20-40% in pregnancies

60-80% of these occur in 1st trimester. In fact 25% of pregnancies end so early that the are not even recognised.

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3
Q

Miscarriage: the definition is?

A

“spontaneous loss of pregnancy before 20 weeks gestation”

After 20 weeks it is considered stillbirth

Miscarriages <6weeks “chemical pregnancies” or “early pregnancy loss”
6-20 weeks “clinical spontaneous miscarriage”

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4
Q

Causes of Miscarriages are?

A
  • Chromosomal anomalies (50%)
  • Structural anomalies
  • Maternal Factors; fibroids, adhesions, diabetes
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5
Q

What is a Threatened Miscarriage?

A

Minor vaginal bleeding no/little pain

Cervix closed

Pregnancy symptoms

no tissue passed

*if fetal heartbeat heard, 95% will continue to term
*puts these patients more at risk for miscarriage

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6
Q

What is an inevitable miscarriage?

A

Heavy vaginal Bleeding

Pain

No tissue passed

may still have vaginal symptoms

Open cervical os

Management is indicated, USS confirms non-viable pregnancy and reveals products of conception in utero

empty sac at 7+ weeks means miscarriage is inevitable

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7
Q

What is an incomplete miscarriage?

A

Passage of products has started but not complete.

Heavy bleeding/clots

pain/cramps

tissue passed

cervical os open

May have pregnancy symptoms

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8
Q

Complete Miscarriage

A

Has occured

Light brown spotting

minimal pain

no more tissue passing

Cervical os closing

symptoms of preg reducing

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9
Q

Missed Miscarriage

A

When pregnancy ends but uterus does not expel its contents.

Light brown spotting

minimal pain

no more tissue passing

Cervical os closed

symptoms of preg reducing

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10
Q

Management of incomplete, inevitable or missed miscarriage?

A

Expectant: wait and see, review 1/52, usually within 2-6/52 will have passed

Natural/private at home: successful in 65% of early miscarriage

Medical:

  • Misoprostol (800micrograms) -
  • if not complete 72/24 second dose may be required
  • F/U day 8/7

Surgical:

  • Suction curettage (ERPOC) under GA/LA
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11
Q

What is an ectopic pregnancy?

A

When embryo implants at a site other than the endometrium of the uterine cavity.

1/50 pregnancies, mainly in fallopian tube.

  • Small amount of dark red blood
    • if ruptured massive haemorrhage, pale, sweaty, unwell, possibly collapsed
    • After rupture, entire abdo tense and tender
  • Unilateral pelvic pain (shoulder tip if ruptured)
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12
Q

Management of Ectopic Pregnancy includes?

A

Surgical: gold standard.

  • laparotomy if in shock, or if laprascopy going to be difficult (inc BMI, previous surgery)
  • Salpingectomy if other tube looks normal.
  • **give anti-D to all Rh neg women

Medical:

  • IM Methotrexate: only if haemodynamically stable, bhcg <5000 and USS are within limits (no fetal HR, gestational sac in adnexum, not ruptured/no free fluid)

Expectant: occassionallly appropriate

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13
Q

What is a molar pregnancy?

A

When a non-viable fertilized egg implants in the uterus and will fail to come to term.

no bleeding

no pain

Sometimes “grape like” tissue (swollen chorionic villi)

Exaggerated pregnancy symptoms

closed cervical os

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14
Q

Management of a molar pregnancy

A

Surgical evacuation via suction curettage

  • THis carries a risk of heavy bleeding
  • FU required at specialist clinic
  • FU serum bhcg every 1-2 weeks till non-detectable, then monthly for 6/12
  • ANTI D for all Rh neg
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15
Q

What are Braxton Hicks Contractions, are they a cause of concern?

A

“false labour contractions” Occur <8 times/hour or <4 times/20 mins; these contractions are not accompanied by bleeding or vaginal discharge and are relieved by resting. No increased risk in preterm labour

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16
Q

What investigations need to be done before a termination can occur?

A

1) Positive B-hcg 2) Endocervical swab: Chlamydia, gonorrhoea 3) High vaginal swab: Trichomonas vaginalis, bacterial vaginosis or candida

17
Q

When can medical or surgical terminations be offered up until?

A

Medical terminations offered up to 5-9 weeks Surgical Terminations offered up to 7-13 weeks

18
Q

What does medical termination consist of How long does it take What are its side effects Success rate?

A

Woman takes 2 tablets 24-48 hours apart to induce abortion at home. Requires 2x clinic visits. Takes 4-6 hours Nausea, vomiting, cramp like pain, bleeding, diarrhoea Success rate >95%

19
Q

What does surgical termination consist of? How long does it take? What are its side effects? Success rate?

A

Removes pregnancy tissue with a suction procedure under sedation (LA/GA). Requires 2x clinic visits, takes 5-10 mins Nausea, vomiting, cramp like pain, bleeding, diarrhoea 99% success rate

20
Q

Medications for surgical termination?

A

Misoprostol 400 mcg (given buccally to soften cervix and increase uterine tone to stop bleeding) Midazolam may also be given Fentanyl + paracervical block given as analgesia

21
Q

How does medical termination occur?

A

1) Mifesprostone (RU-486): 200mcg is given to sensitise the uterus to PG’s and block progesterone release 2) Misoprostol (PG analouge): 400mcg is given 24-48hours later either vaginally or buccally to induce uterine contractions/cervical dilation

22
Q

What type of bleeding is normal after MTOP

A

Woman may experience light bleeding for up to 3/52 post-MTOP **1/100 woman will have severe bleeding or pain**

23
Q

What is Cervical Shock?

A

Occurs when miscarriage is occuring and a clot or pregnancy tissue gets stuck in transit in the cervix

This causes a profound vagal response of hypootension + bradycardia

24
Q

How do we treat cervical shock?

A
  1. Perform Speculum
  2. Remove the POC from the cervical os
25
Q

Should we always assume miscarriage with early pregnancy bleeding or spotting?

A

No, as light bleeding/spotting is common in early pregnancy (25%).

Causes of spotting:

  • Hormone induced breakthrough bleeding ~when a women would usually menstruate
  • Implantation Bleed: from embryo imbedding, lasts 1-2 days
  • Cervical inflammation
  • uterine fibroids
  • Polyps
  • Cervical/vaginal infection
  • Inherited disorders; von willebrands
  • Trauma
26
Q

Risk factors for miscarriage in early pregnancy

A
  • Chromosomal abnormality
  • Smoking
  • Parental genetic abnormality
  • Chlamydia/rubella
  • Previous miscarriage
  • HTN
27
Q

What do we want to know about with a history /assessment of early pregnancy bleeding/pain

A
28
Q

A woman presents acutely unwell with bleeding and/or pain in early pregnancy. What do you do in that acute situation?

A
  1. Perform Drs ABC’s
  2. Obtain IV access
  3. give O2
  4. Start continuously monitoring
  5. Give IV fluids
  6. Request urgent bloods + group&hold, if needed transfuse blood while finding/treating cause