Lipid Lowering Drugs

Question 0

Niacin (vitamin B3)

Answer 0

Inhibits lipolysis in adipose tissue; reduces hepatic VLDL secretion into circulation
***red flushed face decreased by aspirin, Hyperglycemia and Hyperuricemia

Question 1

Statins

Answer 1

Inhibit conversion HMG-CoA reductase to mevalonate

**hepatotoxicity, increased LFTs, rhabdomyolysis

Question 2

Bile acid resins

Cholestyramine, colestipol, colesevelam

Answer 2

Prevent intestinal reabsorption of bile acids; liver must use cholesterol to make more
***tastes bad GI discomfort, decrease absorption of fat soluble vitamins, cholesterol gallstones

Question 3

Cholesterol absorption blockers (ezetimibe)

Answer 3

Prevent cholesterol reabsorption at small intestine brush border
***increased LFTs and diarrhea

Question 4

Fibrates

Gemfibrozil, clofibrate, benzafibrate, fenofibrate

Answer 4

Up regulate LPL– increases TG clearance

*****myositis, hepatotoxicity, increased LFTs, cholesterol gallstones

Question 5

High LDLs

Answer 5

“SEll”

Statins then add ezetimibe

Question 6

High TGs

Answer 6

” It isnt FuN when you have high TGs”

Fibrates then add niacin

Question 7

Low HDLs

Answer 7

Niacin

Question 8

Cholesterol gallstones side effect

Answer 8

Bile acid resins (cholestyramine) and fibrates

Question 9

Increased CKs side effect

Answer 9

Statins and fibrates