PDA

Question 1

first stage within 24 hours of closure by what mechanism

Answer 1

smooth muscle cell contraction

Question 2

second stage over the next 2-3 weeks by what mechanism

Answer 2

fibrosis and intimal and media necrosis (irreversible)

Question 3

why are some congenital malformations still reversible after 24 hours

Answer 3

because cyanotic or mixing lesions keeps the PDA relatively receptive to reopening for the first week

Question 4

what brith weight will 1/3 of preterm infants have a HDS PDA

Answer 4

30%

Question 5

at what age does eisenmengers syndrome become an issue for HDS PDA

Answer 5

2 years

Question 6

what is the quantification of small, moderate and large by Qp:Qs of a PDA

Answer 6

< 1.5, 1.5-2.2, > 2.2

Question 7

what percent of PDAs close spontaneously by 8 weeks

Answer 7

90%

Question 8

what are some indications for PDA closure

Answer 8

large HDS,
NEC,
ICH

Question 9

what is the dose of indomethacin for PDA closure

Answer 9

0.1-0.2 mg/kg q8 for three doses, okay to try two rounds

Question 10

what is the medical failure rate for PDA closure

Answer 10

10%

Question 11

transcatheter closure is successful 85% of the time for ducts of what size or smaller

Answer 11

8mm