T-cell differentiation

Question 1

Th1 cells

Answer 1

Stimulated by IL12 and TNFa

Secrete IL2, IL10, IFNy and TNFa

Protection against intracellular pathogens
Help CD8 cells and macrophages

Question 2

Th17 cells

Answer 2

Stimulated by IL6 and TGF-B

Secrete IL17, IL21 and IL22

Protect against extracellular pathogens:
Help neutrophil recruitment and enhance generation of autoantibodies

Question 3

T-reg cells

Answer 3

Stimulated by TGF-B

Secrete IL10, CD25 and Foxp3

Negative regulation of immune response (keeps it under control)

Question 4

Tfh cells (follicular cells)

Answer 4

Stimulated by IL6, IL-1B and TNFa

Secrete IL2, IL10 and IL21

Promote germinal centre reactions so B-cells become plasma cells secreting IgA and IgG

Question 5

Th2 cells (helper cells)

Answer 5

Stimulated by IL4 and IL6

Secrete IL4, IL5, IL10 and IL13

Protection against Helminth Parasites