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NAGE > Revision 2 > Flashcards

Revision 2 Flashcards

1
Q

sense strand

A

runs in the same base sequence as the mRNA product and protein product

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2
Q

what does gene regulation involve

A

the assembly of a basal transcription complex at TATA box

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3
Q

the basal transcription complex

A

TFIID first to bind to TATA using TATA binding proteins and accessory factors
functions to allow phosphorylation of RNA pol prior to transcription and in presence of additional factors rate is increased
7 factors make up the complex

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4
Q

NFKB

A

TF

increases circulating cytokines

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5
Q

tamoxifen

A

downregulates breast cancer
anti-oestrogen
used as treatment

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6
Q

oestrogen receptor

A

TF

interacts woth steroid for transcription of oestrogen related genes

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7
Q

incidence of breast cancer

A

1 in 10 women

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8
Q

codon

A

3 bases in a mRNA reading frame

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9
Q

triplet

A

3 bases in a DNA sequence

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10
Q

AA Met

A

can be removed after translation

so is not always 1st AA

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11
Q

wobble

A

refers to highly variable 3rd base in a codon

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12
Q

interaction between AA and ATP

A

involves the loss of 2 phosphate groups to give energy and AMP

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13
Q

where are AA bound on tRNAs

A

3’ end

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14
Q

release factors in termination of translation

A

proteins

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15
Q

what causes the release of the protein chain at the end of translation

A

hydrolysis

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16
Q

Replicons

A

plasmids, YACs and bacteriophages

capable of independent replication

17
Q

probes

A

detect specific nucleotide sequences

18
Q

dicer

A

digests dsRNA into 21-25bp fragments by RNAse III like endonuclease activity forming siRNAs

19
Q

RISC

A

RNA induced splicing complex

20
Q

comparison in size of genome between amoeba and a human

A

amoeba geneome 100x more than human

21
Q

miRNA and mRNA

A

miRNA bind several mRNAs to coordinate gene regulation

miRNAs inhibit target mRNAs through base pairing with incomplete complementarity

NAGE (9 decks)

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