Guide to GI Drugs

Question 1

PROTON PUMP INHIBITORS

Answer 1

omeprazole, lansoprazole, pantoprazole

Question 2

PROTON PUMP INHIBITORS - mechanisms of action

Answer 2

irreversible inhibition by covalent modification of the gastric gland parietal cell H+/K+
proton pump = final common pathway

prodrugs - activated in the acidic environment of the canaliculus contributing to their effectiveness and selectivity of action

take PO are absorbed and subsequently delivered to the stomach for activation

Question 3

PROTON PUMP INHIBITORS - major indictions

Answer 3

peptide ulcers, DU or GU

dyspepsia and GORD

helicobacter pylori infection
amoxicillin, metronidazole, clathithromycin in conjunction with omeprazole

Question 4

PROTON PUMP INHIBITORS - uncommon indications

Answer 4

zolinger-ellison syndrome

Question 5

PROTON PUMP INHIBITORS - adverse effects

Answer 5

diarrhoea
headache
abdominal pain
nausea
fatigue
dizziness

increased risk of C.Diff

result in rebound acid hyper secretion upon discontinuation