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Boards.CP.Blood Bank > KIDD,Duffy,MNS > Flashcards

KIDD,Duffy,MNS Flashcards

1
Q

What Kidd phenotype is twice as common in blacks than white?

A

Jk(a+b-)

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2
Q

The Jk(a-b-) phenotype is very rare, what population is it primarily encounted in? (2)

A
  • Finns

- Polynesians

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3
Q

What is the function of the Kidd protein?

A

Urea transport protein

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4
Q

Jk (a-b-) cells are resistant to what?

-Individuals with this phenotype have what kind of defect?

A

Hemolysis in 2M urea

-Mild urine concentrating defect

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5
Q

Kidd phenotype prevalence in Blacks (decreasing order).

A
  • Jk(a+b-) - 60%
  • Jk(a+b+) - 30%
  • Jk(a-b+) - 10%
  • Jk(a-b-) - rare
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6
Q

Kidd phenotype prevalence in Whites (decreasing order).

A
  • Jk(a+b+) - 50%
  • Jk(a+b-) - 30%
  • Jk(a-b+) - 20%
  • Jk(a-b-) - rare
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7
Q

What type of an antibodies are Kidd antibodies?

  • Temp
  • Class
  • Acquisition
A
  • Warm reacting
  • IgG antibodies
  • Acquired only through exposure
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8
Q

What are Kidd antibodies notoriously known for?

A

Difficult to detect

“tricky Kidd”

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9
Q

Why are Kidd antibodies difficult to detect?

A
  • Display dosage and may only react with homozygous cells (may result in false-negative crossmatch)
  • Tend to fall below the threshold for detection over time

*Historical Kidd Abs is reason enough to give Kidd antigen negative blood (CHECK BLOOD BANK RECORDS!)

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10
Q

Kidd antibodies most often only react at what phase?

A

AHG

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11
Q

Kidd antigens are _____ by enzymes.

A

Enhanced

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12
Q

What is the most common cause of delayed hemolytic transfusion reactions?

A

Kidd

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13
Q

Does Kidd cause hemolytic disease of newborn?

-Why?

A

Rarely

-Weakly expressed by fetus

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14
Q

What 2 antigens comprise the Duffy system?

A

Fya and Fyb

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15
Q

Duffy antigens are present on Duffy associated receptor for chemokines (DARC), which is a receptor for what?

A

Plasmodium vivax (malaria)

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16
Q

Which phenotype is more common:

-F(a-b+) or F(a+b-)

A

F(a+b-)

17
Q

What is the Duffy phenotype that differs most between blacks and whites?
-Whats the explanantion?

A

Blacks - Fy(a-b-) is common (68%); Whites - Rare

-confers resistence to Plasmodium vivax

18
Q

Because of differeing mechanisms of Duffy negativity in whites and blacks, what is true about the development of Fy antibodies?

A 
Most Fy(a-b-) Blacks do NOT form anti-Fy Ab
-Fy(a-b-) Whites do for an anti-Fy Ab
19
Q

What type of an antibodies are Duffy antibodies?

  • Temp
  • Class
  • Acquisition
A
  • Warm
  • IgG
  • Acquired through exposure
20
Q

Duffy Antibodies (do or do not) show dosage effect.

A

Duffy antibodies show dosage

21
Q

Duffy antigens are _______ by enzymes.

A

Destroyed

22
Q

T/F: Duffy antibodies are capable of causing HTR and HDFN.

A

True

23
Q

MNS antigens - Which genes display genetic linkage?

A

MN and SsU genes

24
Q

MNS antigens - Most frequent haplotypes?

A

Ns and Ms

25
Q

MNS antigens - M and N antigens are found on what?

A

Glycophorin A

26
Q

What is are the phenotype prevalence of MNS antigens?

A
  • M+N+ (50%)
  • M+N- (25%)
  • M-N+ (25%)
27
Q

Where do the S, s, and U antigens reside?

A

Glycophorin B

28
Q

S, s, and U frequencies?

A

-s and U - high prevalence (98%)
S antigen
-Whites (50%)
-Blacks (30%)

29
Q

Anti-M antibodies:

  • Temp
  • Class
  • Clinical Sig or Not
  • Acquisition
A

MNS antibodies:

  • Cold
  • IgM
  • NOT clinically significant
  • Naturally occuring
30
Q

Why are anti-N antibodies rare?

A

epitope on Glycophorin B has N like antigenicity

31
Q

When are Anti-Nf antibodies formed?

A

Dialysis patients exposed to formaldehyde

-Induced formation of Nf antigen on RBCs

32
Q

Anti-S, s, U Antibodies:

  • Temp
  • Class
  • Clinical sig?
  • Acquisition
A

Anti-S, s, U Antibodies:

  • Warm
  • IgG
  • Clinically Significant
  • acquired following exposure
33
Q

Do MNS antibodies display dosage?

A

Yes

34
Q

M and N antigenicity is _______ by enzymes.

A

Destroyed

Boards.CP.Blood Bank (13 decks)

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