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Genomics > Block 4 > Flashcards

Block 4 Flashcards

1
Q

Pro/Con of Cost-consequence?

A

Good = Straightforward cost results

Bad = difficult to make value comparison between alternatives

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2
Q

Tricyclic antidepressants involve which CYP?

A

CYP2C19 + CYP2D6

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3
Q

Antipsychotics + Genotype?

A

Little evidence that shows efficacy is a factor regarding CYP2D6 or CYP2C19, other CYPs are used

Most info focus in drug-drug interactions

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4
Q

Poor metabolizers + Antidepressants?

A

Decrease dose by 50%

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5
Q

Pro/Con of Cost-utility?

A

Good = incorporates quality of life

Bad = can be difficult to interpret

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6
Q

Intermediate metabolizers + Antidepressants?

A

Decrease dose by 25% then evaluate response

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7
Q

Pro/Con of Cost-benefit?

A

Good = strong theoretical foundation

Bad = viewed with skepticism

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8
Q

Analytical Validity
Clinical Validity
Clinical Utility

How well does the diagnostic test differentiate responders vs non-responders or predict AE to a specific drug?

A

Clinical Validity

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9
Q

Pro/Con of Cost-effectiveness?

A

Good = relevant for clinicians/health care decision makers

Bad = cannot compare interventions between disease states

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10
Q

Gene prevalence vs penetrance?

A

Prevalence = how common

Penetrance = Variant and drug response

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11
Q

What drug transporters are involved in GI tract or BBB?

A

Pgp encoded by ABCB1

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12
Q

Pro/Con of Cost-minimization?

A

Good = simple

Bad = effectiveness of alternatives are equal

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13
Q

What’s up with SSRI used for depression?

A

Inhibitor of CYP2C19 + CYP2D6

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14
Q

Carbamazepine (antiepileptic) + Genotype?

A

HLA-B*1502 = black box warning of Asian ancestry

Can cause skin reactions, stevens-johnson syndrome

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15
Q

Phenytoin (antiepileptic) + Genotype?

A

HLA-B*1502 = Asian + European

Europeans are recommended for CYP2C9 testing and 25% lower dose in poor metabolizer status

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16
Q

Ultra-metabolizers + Antidepressants?

A

Avoid therapy

17
Q

Pro/Con of Cost-of-illness?

A

Good = quantifies cost of illness

Bad = perspective will affect results

18
Q

Analytical Validity
Clinical Validity
Clinical Utility

Does testing improve clinical outcome vs empiric treatment alone?

A

Clinical Utility

19
Q

What are some short-term goals for improving treatment of cancer?

A
  1. Innovative clinical trials
  2. Combination therapies
  3. Reduction of drug resistance
20
Q

Analytical Validity
Clinical Validity
Clinical Utility

How well does the diagnostic test measure what it is intended to measure?

A

Analytical Validity

Genomics (11 decks)

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