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OCN > Individual Chemo > Flashcards

Individual Chemo Flashcards

1
Q

Alkylating Agent Chemo’s

A 
Cell cycle NON-SPECIFIC
Cisplatin
Oxaliplatin
Carboplatin
BEndamustine
Cyclophosphamide
Ifosphamide
Melphalan
BEndamustine
Busulfan
Thitepa
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2
Q

Antimetabolites- Antifolates chemo names

A

Methotrexate
Premetrexed
Pralatrexate

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3
Q

5-Fluropyrimidines chemo names

A

Cell cell SPECIFIC
Flurouracil
Capecitabine
Flourdine

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4
Q

Cytosine Analogues names

A 
Cell cycle SPECIFIC
Azacitidine (Vidaza)
Decitabine
Cytarabine (ara-C)
Fludarabine
Gemcitabine
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5
Q

Anthracyline and Antitumor antibiotic names

A 
Cell cycle SPECIFIC
Doxorubicin
Epirubicin
Idarubicin
Mitoxantron
Belong in
Vixeos (liposomal daunorubicin and cytarabine)
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6
Q

antimicrotubule chemo names

A 
Vincristine
Vinblastine
Binorelbine
Vindesine
Paclitaxel
Docetaxel
Ixabepilone
Eribulin
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7
Q

Topoisomerase Inhibitor names

A

Cell cycle SPECIFIC
Irinotecan
Toptecan
Etoposide (VP-16)

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8
Q

Nitrosureas names

A

Cell cycle NON-SPECIFIC
Cross blood brain barrier

Carmustine
Lou stone
STreptozocin

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9
Q

Cisplatin side effects

A

Ototoxicity

Renal toxicity

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10
Q

Oxaliplatin side effects

A

Cold neuropathy

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11
Q

Carboplatin side effects

A 
Hypersensitivity reaction (7th dose)
- may see itching, palms/feet
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12
Q

Cyclophosphamide and Ifosfamide side effects

A

Hemorrhagic cystitis - used Mensa (usually equal dose)

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13
Q

Methotrexate side effects

A

Renal toxicity

High dose - requires leucovorin rescue

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14
Q

Pralatrexate side effects

A

Need to administer folic acid, steroids and B12

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15
Q

Flurouracil side effects

A

Angina

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16
Q

Capecitabine side effects

A

Hand-foot syndrome

17
Q

Azacitidine side effects

A

(Vidaza)

CHF

18
Q

Decitabine side effects

A

TLS

19
Q

Cytarabine side effects

A

Cerebellar toxicity
High dose - conjunctivitis (use steroid eye drops)
Neurotoxicity

20
Q

Fludarabine side effects

A

TLS

21
Q

Gemcitabine side effects

A

Pulmonary toxicity

22
Q

Doxorubicin/Daunorubicin side effects

A

Cell cycle SPECIFIC
Lifetime cumulative dose
Radiation recall of XRT dermatitis
Red urine

23
Q

Liposomal doxorubicin side effects

A

Hand foot syndrome

24
Q

Epirubicin/Idarubicin side effects

A

Red urine

25
Q

Mitoxantrone side effects

A

Blue urine and sclera

26
Q

Bleomycin side effects

A

Pulmonary fibrosis

27
Q

Vyxeos (liposomal daunorubicin and cytarabine) side effects

A

Myelosupression
Cardiotoxicity
Hypersensitivity
Copper overload

28
Q

Vincristine side effects

A

Cell cycle SPECIFIC
FATAL if intrathecal
Constipation

29
Q

Paclitaxel/Docetaxel side effects

A

Cell cycle SPECIFIC
Vesicant
Anaphylactic reactions (can be severe)
Myalgia

30
Q

Irintoecan Side effects

A

Cell cycle specific
Diarrhea (early and late)
Give atropine for early onset
Give Imodium for late diarrhea

31
Q

Etoposide side effects

A

Cell cycle specific

Hypotension - give over 60 min

32
Q

Asparaginase side-effects

A 
Anaphylactic reactions
Hepatotoxicity
Coagulopathy
Pancreatitis
Cell cycle NON-SPECIFIC
33
Q

Treninoin (ATRA) and Arsenic side-effects

A

QT prolongation - could lead to Torsades
Electrolyte imbalance
Cough and dyspnea (retinoids acid syndrome)
–white cells go to lungs - manage with steroids

34
Q

Hydrea side effects

A

bone marrow depression
Mucositis
Secondary malignancy

35
Q

Carmustine side effects

A

Cross blood brain barrier
Part of BEAM regimen for lymphoma
Pulmonary fibrosis

36
Q

STreptozocin side effects

A

Renal toxicity
Bone marrow depression
Hyperglycemia

OCN (6 decks)

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