Paediatrics 3 Flashcards

1
Q

Which antigens are associated with Coeliac Disease?

A
  • Class II HLA-DQ2 and -DQ8
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2
Q

What is the pathophysiology behind Coeliac disease?

A

Heightened T- and B- lymphocyte responses to wheat gluten and other prolamines

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3
Q

List some non-GI manifestations of Coeliac disease.

A
  • Dermatitis herpetiformis
  • Dental enamel defects
  • Osteoporosis: Low bone mineral density
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4
Q

Which antibodies are associated with Coeliac disease?

A
  • Antigliadin
  • Anti-endomysial
  • Tissue transglutaminase
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5
Q

What is the criteria for diagnosis of Coeliac disease in childhood?

A
  • Characteristic histology (Marsh type III a - c)
  • Positive serology
  • Symptomatic response to gluten exclusion
  • Resolution of antibodies
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6
Q

List some risk factors for coeliac disease.

A
  • Positive FHx
  • Diabetics
  • Short stature
  • Down’s syndrome
  • Thyroid disorders
  • IgA deficiency
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