8: Drugs for Pain

Question 1

analgesic

Answer 1

drug that relieves pain without causing LOC

Question 2

hyperesthesia

Answer 2

increased sensitivity to stimulation

Question 3

dysesthesia

Answer 3

an unpleasant abnormal sensation, spontaneous or evoked

Question 4

allodynia

Answer 4

pain resulting from a stimulus that normally doesnt cause pain

Question 5

nociceptive pain

Answer 5

perception of input from a nociceptor

Question 6

neuropathic pain

Answer 6

arises from abnormal neural activity secondary to disease, injury, or dysfunction of the NS

Question 7

COX1 vs COX2

Answer 7

• COX1: expressed all the time in all tissues, role in physiologic stimuli
• COX2: induced in some tissues sometimes, has a physiologic role in kidney and a prominent role in pathologic stimuli

Question 8

mild, moderate, and severe aspirin toxicity

Answer 8

1. mild: ringing in ears, N/V
2. moderate: N/V, hyperventilation, flushing, sweating, thist, HA, diarrhea, tachy
3. severe: resp alkalosis, hemorrhage, confusion, pulmonary edema convulsion

Question 9

how does acetaminophen not have anti-inflam properties, not cause GI ulcers, not suppress platelets, and not impair renal function?

Answer 9

inhibits prostaglandin synthesis in CNS, but not in the periphery!

Question 10

safe dose of acetaminophen in a day

Answer 10

3g/day (2g/day if liver disease)