8. Obesity Flashcards
(49 cards)
obesity is associated with
incr morbidity and mortality
short term pharmacologic obesity treatment
phentermine
benzphetamine
diethylproprion
phendimetrazine
long term pharmacologic obesity treatment
orlistat
naltrexone/bupropion
liraglutide
semaglutide
tirzepatide
obesity
abnormally high amount of adipose tissue compared with lean muscle mass
obesity is what % over ideal body weight
> = 20 %
direct measures of body comp
underwater weighting
skin fold measurement
BIA
DEXA
indirect measures of body comp
BMI
BSA
IBW
LBW
PNWT
overweight BMI
25-29.9
class 1 obesity
30-34.9
class 2 obesity
35-39.9
class 3 obesity
> =40
LBW =
TBW - fat weight
LBW compared to IDW
LBW > IDW
LBW ~
LBW ~ 1.3*IBW
obesity oral abs
unchanged
obesity transderma/subQ absorption
decr subQ abs
obesity Vd
incr Vd for lipophillic drugs
hydrophylic drugs in obese pts
little change in Vd
hepatic blood flow in obesity
increased hepatic blood flow
what does incr hepatic blood flow mean
incr clearance of high extraction ratio drugs
high extraction ratio drugs
propofol
ketamine
morphine
obesity drug half life
incr half life due to incr Vd for lipophillic drugs
hydrophillic drug clearance
incr renal clearance
risk of failed regional block
1.5* higher when BMI > 30