Pathology

Question 1

genetic mutation of type V Collagen
def wich enzime

Answer 1

Ehlers-Danlos
procollagen peptidase (Cleavage of procollagen C- and N- chains)

Question 2

Adolescent athlete

Knee pain worsen with Extension

Answer 2

Osgood-Schlatter Disease

Avulsion TIBIAL TUBERCULE (jumping)
Secondary ossification center

Question 3

Paget disease of the Bone- Osteitis deformans
M-CSF & RANK-L – NFkB Osteoclast / mixed / osteoblast
Sx.
Rx
Tx

Answer 3

Sx: bone thickening and hearing loss
Rx: Osteosarcoma
Tx: bisphosphonates

Question 4

Gradual onset of symptoms
Pleuritic
Fever
Arthralgias
Erythematous rash

ask for…

Answer 4

Anti-double strand DNA antibodies

High Specificity

Question 5

high Osm
-
low ICF 
low ECF
cause?

Answer 5

Diabetes Insipidus
high serum osmolarity
low urine osmolarity

Question 6

ANTICARDIOLIPIN…
LUPUS ANTICOAGULANT…
produce?

Answer 6

Antiphospholipid Syndrome
Anticardiolipin__ FALSE + VDRL/RPR
Lupus Anticoagulant__ kPTT prolonged (but)

HYPERCOAGULABILITY STATE
#Thrombosis
#Preganancy Loss-Abortion