Week 3

Question 1

In general terms, what is the First stage of Aerobic ATP production ?

Answer 1

Generation of Acetyl- CoA

Question 2

In general terms, what is the Second stage of Aerobic ATP production ?

Answer 2

Oxidation of Acetyl CoA (Krebs Cycle)

Question 3

In general terms, what is the Third stage of Aerobic ATP production ?

Answer 3

Oxidation Phosphorylation (ATP production in ETC)

Question 4

Where is Acetyl CoA generated?

Answer 4

Mitochondria

Question 5

What is the primary function of the Krebs cycle

Answer 5

Produce electron carriers;

NADH, FADH, H+

Question 6

How many turns of the Krebs Cycle result from 1 Glucose Molecule ?

Answer 6

2

Question 7

What is the first step of the Krebs cycle?

Answer 7

Removal of carbon from Pyruvate to form Acetyl-CoA

Question 8

What enzyme is responsible for the transformation of Pyruvate into Acetyl-CoA ?

Answer 8

Pyruvate Dehydrogenase

Question 9

What is the first oxidation reduction reaction of the Krebs cycle and what results from this?

Answer 9

Isocitrate > alpha-Ketoglutarate (enzyme = isocitrate dehydrogenase)

Results in : NADH and CO2

Question 10

What is the rate limiting enzyme of the Krebs cycle

Answer 10

Isocitrate Dehydrogenase

Question 11

What is the second oxidation reduction reaction of the Krebs cycle and what results from this?

Answer 11

Alpha-ketoglutarate > Succinyl-CoA (enzyme = alpha-ketoglutarate Dehydrogenase)

Results in; NADH &CO2

Question 12

In the Krebs cycle, What does the reaction of Succinyl-CoA > Succinate produce ?

Answer 12

GDP > GTP > ADP > ATP

Question 13

What reaction produces FADH in the Krebs cycle ?

Answer 13

Succinate > Fumarate

Question 14

What is the last step in the Krebs Cycle and what does it result in?

Answer 14

Malate > Oxaloacetate

Results in; NADH

Question 15

What stimulates the Krebs cycle

Answer 15

ADP & Calcium

Question 16

What inhibits the Krebs Cycle?

Answer 16

ATP negative feedback

Question 17

What are the requirements of Aerobic Energy generation?

Answer 17

Acetyl-CoA

Oxygen

Efficient waste removal (CO2)

Question 18

2 physiological factors influencing VO2 Max

Answer 18

Ability to deliver O2 to the muscle

Ability of muscles to use O2 and produce ATP aerobically

Question 19

Name the 6 factors contributing to EPOC

Answer 19

Resynthesis of PC in the muscles

Lactate conversion to Glucose

Restoration of muscle and blood O2 stores

Elevated body temp.

Post-exercise elevation of HR and RR

Elevated hormones

Question 20

Define Lactate Threshold

Answer 20

Point at which blood lactate will raise systematically during incremental exercise

Question 21

How will lactate threshold be different in trained subjects vs untrained ?

Answer 21

It will occur at a higher percent of the individuals VO2 max