Test 4 Review

Question 1

What is the only third generation Cephalosporin that covers Pseudomonas?

Answer 1

Ceftazidime

Question 2

What are the drugs of choice for ESBL?

Answer 2

Carbapenems

Question 3

Adverse effects of Fluoroquinolones include _______, peripheral neuropathy, tendonitis, and _____________.

Answer 3

AE include QTC prolongation, peripheral neuropathy, tendonitis, and hyperglycemia

Contraindicated in pregnancy and children

Question 4

Which Tetracycline has the broadest coverage? What does it cover?

Answer 4

Gram + including MRSA and Gram - (not including pseudomonas) → All Tetracyclines

Tigecycline: + anaerobic coverage + VRE

Question 5

Name 3 adverse effects of Tetracyclines

Answer 5

Nausea and vomiting (Tygacil/Tigecycline)
Higher vestibular toxicities (vertigo) - Minocin/Minocycline
Teratogenic - bone deformity, teeth staining
Avoid both in pregnancy and children less than 8
Photosensititivy

Question 6

True or False: Tetracyclines are good for blood and urine infections

Answer 6

False, They are good for bone and skin infections due to their high volume of distribution

Question 7

____ is used in COPD exacerbations, whereas ____ is rarely used due to inhibition of CYP 450 enzymes, GI intolerance and more frequent dosing. Both drugs also exhibit post antibiotic effect.

Answer 7

Azithromycin Clarithromycin

Question 8

28 y/o male tests positive for Chlamydia trachomitis. Which macrolide do you think will be ordered to be given as treatment?

Answer 8

Azithromycin

Question 9

You have a 25 year old female who presents with a fungal infection in the urinary tract. What drug do you anticipate will be prescribed? Why?

Answer 9

Fluconazole – it’s the only antifungal that concentrates in the urine

Question 10

Which medications can be considered as first line treatment for uncomplicated acute cystitis?

Answer 10

Macrobid, Bactrim

Question 11

C diff drugs

Answer 11

Vanco

Vanco + flagyl