(13.1) Drugs used in Cardiac Arrhythmias (Konorev)

Question 1

Answer 1

D. Artiral CM, Purkinje fibers, ventricular CM

Question 2

What are the Class 1 antiarrhythmic drugs MOA?

Answer 2

Sodium channel blocking drugs

Question 3

What are the class 1A drugs?

Answer 3

Quinidine

Procainamide

Disopyramide

Question 4

What are the class 1B drugs?

Answer 4

Lidocaine

Mexiletine

Question 5

What are the class 1C drugs?

Answer 5

Felecainide

Propafenone

Question 6

What are the class 2’s MOA?

Answer 6

Beta blockers

Question 7

What are the class 2 drugs?

Answer 7

Esmolol

Propranolol

Question 8

What is the MOA of class 3 drugs?

Answer 8

Potassium channel blocking drugs

Question 9

What are the class 3 drugs?

Answer 9

Amiodarone

Sotalol

Dofetilide

Ibutilide

Question 10

What is the MOA of class 4 drugs?

Answer 10

Cardioactive calcium channel blockers

Question 11

What are the class 4 drugs?

Answer 11

Verapamil

Diltiazem

Question 12

What is a “miscellaneous agent” used as an antiarrhythmic drug?

Answer 12

Adenosine

Question 13

What will occur when a Class 1A drug is given?

Answer 13

Block sodium channels

State-dependent block occurs

Block potassium channels

Prolong QRS and QT intervals of EKG

Question 14

What occurs when a class 1B drug is used?

Answer 14

Block sodium channels

State-dependent block

***DOES NOT BLOCK POTASSIUM CHANNELS

Question 15

What happens when class 1C drugs are used?

Answer 15

Block sodium channels

State dependent block (prefers open sodium channels)

Blocker CERTAIN potassium channels

Prolongs QRS interval

Question 16

Answer 16

A. Decreased outward K+ flux

Question 17

How do class 2 drugs work on the heart?

Answer 17

Sympathetic effect on sinoatrial nodal cells

Question 18

What happens when a class 3 drug is used?

Answer 18

Block potassium channels

prolonged QT

Question 19

Answer 19

C. Esmolol : increased PR interval