translation stoppers Flashcards

1
Q

Streptomycin

A

binds to 30S subunit to disrupt initiation of translation

Binds where fmet-tRNA is

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2
Q

Clindamycin & Erythromycin

A

-bind to 50S subunit to disrupt translocation of ribosome

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3
Q

what does clindamycin used to treat?

A

used to treat pertussis

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4
Q

Shiga Toxin & Ricin

A

-binds to 60S subunit to disrupt elongation

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5
Q

Diphtheria toxin

A

-inactivates EF2-GTP and inhibits elongation

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6
Q

Tetracyclines

A

bind to the 30S subunit to disrupt elongation

Blocks aminoacyl-tRNA to ribosomal complex

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7
Q

Puromycin

A

causes premature chain termination in both prok/euks
Forms a puromyclated chain at 3’ end of aminoacylated-tRNAs which leads to premature chain release
Stops ribosome from functioning

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8
Q

Peptidyl transferase activity

A

-housed in large subunits

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9
Q

Chloramphenicol

A

inhibits peptidyl transferase

Prokaryotes & mitochondria

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10
Q

Cycloheximide

A

inhibits peptidyl transferase

Eukaryotes

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