Immuno Set 6 Flashcards
Bowden
A child presents with a history of repetitive viral respiratory infections since one year of age. He is diagnosed with a mutation in the antigen-processing pathway. Which of the following is the most likely mutated molecule?
a. CLIP
b. MHC-DM
c. Phagolysosome formation
d. Reactive oxygen species (ROS) activation
e. TAP
e. TAP
A47-year old male presents with a bacterial infection in his third finger of his right hand. Which pair of molecules is necessary for recognition of the specific bacterial antigen?
a. MHCClassI/CD3
b. MHCClassI/TCR
c. MHC Class II /CD25
d. MHCClassII/CD3
e. MHCClassII/TCR
e. MHCClassII/TCR
Patients with Bare Lymphocyte Class II are participating in a clinical trial investigating gene therapy targeting the mutated protein. Which is the most likely molecule under investigation?
a. CLIP
b. Proteosome
c. TAP
d. Tapasin
e. β2 microglobulin
a. CLIP
You are designing an experiment to activate T cells. You want to ensure the antigen is presented to T cells in order for them to be activated. Which of the following antigenic properties is key in your investigation?
a. Ability of the antigen to bind within MHC/HLA
b. Antigenic epitopes lead to a protective response humoral response
c. How many carbohydrate residues the antigen contains
d. Third dimensional structure of the antigen
e. The antigen is an unconjugated hapten
a. Ability of the antigen to bind within MHC/HLA
We have the ability to express both haplotypes of HLA on cell surfaces at the same time. This ability allows cells to express a vastly increased variety of peptides. This function is referred to as:
a. Co-dominant expression
b. Complete dominant expression
c. Recessive expression
d. Alternative RNA splicing
e. Clonal selection
a. Co-dominant expression
After signaling from the Pre-B cell receptor, one of the two immunoglobulin alleles is functionally inactivated for μ heavy chain recombination. This process is necessary for:
a. decreasing the amount of RAG expression.
b. development of junctional diversity.
c. editing of κ and λ chains.
d. increasing the variability of the epitope that can bind.
e. maintaining specificity of the B cell receptor.
e. maintaining specificity of the B cell receptor.
After signaling from the Pre-B cell receptor, one of the two immunoglobulin alleles is functionally inactivated for μ heavy chain recombination. This process is referred to as:
a. Allelic exclusion
b. Alternative transcription expression
c. Co-dominant expression
d. Positive selection
e. Somatic recombination
a. Allelic exclusion
At which developmental stage does a T cell first express a functional TCR?
a. Activated T cell
b. Immature T cell
c. Pre-T cell
d. Pro-T cell
e. Stem cell
b. Immature T cell
A patient is referred for a consult due to multiple recurrent viral and bacterial infections throughout his lifetime. The bacterial infections resolve with antimicrobial treatment. A CBC with differential demonstrates a decreased number of lymphocytes in the peripheral blood. Flow cytometry demonstrates decreased number of CD3+ and CD19+ lymphocytes. Where would the most likely defect in lymphocyte development be found in this patient?
a. Activation induced deaminase (AID) activity
b. MHC/HLA Class II expression
c. CD40 ligand expression
d. Recombinase activating genes (RAG)s protein expression
e. Terminal deoxyribonucleotidyl transferase (TdT) production
d. Recombinase activating genes (RAG)s protein expression
What event moves a T cell from Pro-T to Pre-T in the T cell development process?
a. CD40 expression
b. Expression of a functional TCR
c. IL-2 secretion
d. Recognition of self MHC/HLA
e. α surrogate chain expression
e. α surrogate chain expression
