Cancer chemo Flashcards
1
Q
Toxic effects of chemo
A
BM suppression (anaemia, infection prone, impaired healing)
hair loss
damage to GI epi
sterility
2
Q
Classes of chemo
A
Alkylating agents Anti-metabolites Cytotoxic antibodies Microtubule inhibitors Steroid hormones/ antagonists
3
Q
alkylating agent mechanism
A
Binds with DNA and interferes with transcription and replication
4
Q
Example of alkylating agent
A
cyclophosphamide
melphalan
5
Q
antimetabolites mechanism
A
interferes with nucleotide/DNA synthesis e.g. purine, pyramidine
6
Q
examples of antimetabolites
A
methotrexate
fluoro-uracil
mecaptopurine
7
Q
cytotoxic ab mechanism
A
intercalates into DNA and impairs synthesis and function
8
Q
examples of cytotoxic ab
A
dactinomycin
doxorubicin
9
Q
example of microtubule inhibitor
A
vincristine
10
Q
microtubule inhibitor mechanism
A
blocks tubulin polymerisation and normal spindle formation
11
Q
Steroid antagonist examples
A
Tamoxifen
Bicalutamide
