Chapter 9: Drug Therapy for Coagulation Flashcards
drugs that prevent formation of new clots and extension of clots already present; do not dissolve formed clots
Anticoagulants
drugs that prevent one or more steps in the prothrombotic activity of platelets
Antiplatelets
object that migrates through the circulation until it lodges in a blood vessel, causing occlusion; may be a thrombus, fat, air, amniotic fluid, a bit of tissue, or bacterial debris
Embolus:
chronic blood disorder characterized by the overproduction of platelets by megakaryocytes in the absence of another cause
Essential thrombocythemia:
enzyme that breaks down the fibrin meshwork that stabilizes blood clots; also referred to as plasmin
Fibrinolysin:
prevention or stoppage of blood loss from an injured blood vessel and is the process that maintains the integrity of the vascular compartment
Hemostasis
immune-mediated adverse effect that leads to thrombogenesis resulting in a decrease in platelet count associated with heparin administration in patients with detectable HIT antibodies
Heparin induced thrombocytopenia (HIT)
enzyme that breaks down the fibrin meshwork that stabilizes blood clots; also referred to as fibrinolysin
Plasmin:
inactive protein found in many body tissues and fluids
Plasminogen
formation of a blood clot
Thrombogenesis:
breakdown or dissolution of blood clots
Thrombolysis
drugs that dissolve blood clots
Thrombolytics
formation of a blood clot
Thrombosis
Blood clot
Thrombus
Why is it necessary to give heparin intravenously?
It is necessary to give heparin intravenously or subcutaneously, because the gastrointestinal (GI) tract does not absorb the drug.