Antibioitcs

Question 1

what are the glycopeptides?

Answer 1

vancomycin and teicoplanin

Question 2

what are the macrolides?

Answer 2

erythromycin, clindamycin, clarithromycin

Question 3

what are the fluoroquinolones?

Answer 3

ciprofloxacin, norfloxacin, levofloxacin, moxifloxacin

Question 4

what are the aminoglycosides?

Answer 4

gentamicin, streptomycin

Question 5

what are the sulfonamides?

Answer 5

sulfamethoxazole, dapsone

Question 6

what are the tetracyclins?

Answer 6

tetracycline, doxycycline, minocycline, tigecycline

Question 7

what are the beta lactams?

Answer 7

penicillin, cephalosporin, carbapenems, monobactams

Question 8

glycopeptide moa

Answer 8

glycopeptides very bulky, binds to d-ala dipeptide and blocks off transpeptidase

Question 9

daptomycin moa

Answer 9

lipid tail inserted into membrane forming an ion conducting channel from which K+ ions can leak out.
this depolarises the membrane causing cell death

Question 10

fosfomycin moa

Answer 10

binds to cysteine residue, inactivating bacterial cell wall enzyme Mur A which catalyses the first step of peptidoglycan synthesis

Question 11

sulfa moa

Answer 11

sulfa similar to PABA, inhibit first step of folate pathway

Question 12

trimethoprim moa

Answer 12

inhibits dihydrofolicacid reductase, inhibitng the last step

Question 13

tetracyclin moa

Answer 13

binds to 30s subunit prevents tRNA from binding to A site

Question 14

aminoglycoside moa

Answer 14

binds to 30s subunit causing mismatching of mRNA and tRNA which creates junk proteins

Question 15

chloramphenicol moa

Answer 15

binds to 50s subunit and prevents transpeptidation reaction

Question 16

macrolides moa

Answer 16

binds to 50s subunit and interferes with peptide chain synthesis

Question 17

fluoroquinolone moa

Answer 17

inhibits topoisomerases involved in DNA supercoiling

Question 18

rifampicin moa

Answer 18

RNA polymerase inhibitor