CNS Tumors

Question 1

von HIppel has a lot of ______ production, leading to overproduction of angiogenic growth factors and EPO and results in Hemangioblastoma

Answer 1

HIF

Question 2

Schwannoma, meningioma, and Ependymoma all are caused by which syndrome?

Answer 2

Neurofibromatosis 2

Question 3

Glioblastoma 3 Key Histo findings

Answer 3

1. Ring-Enhancing lesion
2. Necrosis
3. Butterfly Lesion

Question 4

Oligodendroglioma is your favorite Histo CNS tumor because:

Answer 4

It looks like Eggs!

Question 5

Seeing dirty Horner wright rossettes means its a _____ tumor

Answer 5

Medulloblastoma

Question 6

True rosettes in 4th ventricle or spinal cord lead you to suspect ______ tumors

Answer 6

Ependymoma

Question 7

Whorls on Histo with NF2 mutations, calcifications, and a Dural tail makes you suspect ____ tumors

Answer 7

Meningiomas

Question 8

Among the easiest tumors to find is Meningiomas b/c histologically it shows _____

Answer 8

Whorls

Question 9

Key appearance of Craniopharyngioma

Answer 9

Big spaced out leafy pink chunks

Question 10

SEGA is usually found near _______

Answer 10

Ventricles

Question 11

Stringy tumor often affecting children cerebrellum

Answer 11

Pilocytic Astroytoma

Question 12

Medulloblastoma grade?

Answer 12

IV

Question 13

NFT1 aka Von recklinghausen disease causes Neurofibromas as well as which 2 special tumors?

Answer 13

1. Optic Gliomas

2. Pheochromocytomas

Question 14

2 Histo findings for Pilocytic Astrocytoma

Answer 14

1. Rosenthal (pink) fibers

2. Hair-like processes

Question 15

The bloodiest tumor is probably _______

Answer 15

Hemangioblastoma

Question 16

2 Key histo findings in Medulloblastoma

Answer 16

1. Hormer Wright Rossette (dirty)

2. Snyaptopysin staining to show External granular layer?

Question 17

Fried egg nuclei with DEEP pink “chickenwire vasculature” leads you to suspect _______ tumor

Answer 17

Oligodendroglioma

Question 18

Glioblastoma Grade

Answer 18

IV (The worst)

Question 19

NF2 causes which 3 tumors?

Answer 19

1. Schwannoma
2. Meningioma
3. Ependymoma

Question 20

Subependymal Giant Cell Astrocytoma (SEGA) is caused by _______ ____ complex

Answer 20

Tuberous Sclerosis

Question 21

Spindle-shapes, Antoni and Verocay bodies with rods and waves a pink/light pink are key clues for the “popular” _____ tumor

Answer 21

Schwannoma

“Everyschwon knows them”

Question 22

Irregular, elongated, crowded nuclei staining GFAP positive lead to the conclusion of ______ _____ type of tumors

Answer 22

Diffuse Astrocytoma

Question 23

Seeing super pink, leafy, spaced out squamous neural chunks would make you think of _______ tumors

Answer 23

Craniopharyngioma

Question 24

A cerebral ring-enhancing lesion with butterfly lesion that presents with pale necrosis is probably _____ tumor

Answer 24

Glioblastoma