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Nino OITE > Other Pharmacology > Flashcards

Other Pharmacology Flashcards

1
Q

Mechanism of: NON-NITROGEN BISPHOSPHONATES

A

osteoclast APOPTOSIS (ATP competitive inhibition)

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2
Q

Mechanism of: NITROGEN BISPHOSPHONATES

A

osteoclast DYSFUNCTION (farnesyl pyrophosphate synthase inhibition in HMG-CoA reductase pathway)

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3
Q

Mechanism of: CORTICOSTEROIDS

A

PHOSPHOLIPASE A2 inhibition

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4
Q

Mechanism of: DENOSUMAB

A

RANKL inhibition

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5
Q

Mechanism of: TERIPARATIDE

A

parathyroid hormone, anabolic – activates osteoblasts and osteoclasts (blast > clast) – should only be used for 2 years max 2/2 risk of osteosarcoma– (off label use to treat fx non-unions reported)

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6
Q

Mechanism of: ABATACEPT

A

MHC receptor antagonist

– recombinant fusion protein that targets MHC-R on antigen presenting cells to block T-cell activation

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7
Q

Mechanism of: ANAKINRA

A

IL-1 receptor antagonist

– blocking IL-1’s pro-inflammatory signaling pathway

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8
Q

Which DMARDs are antibodies to TNF-alpha?

A

INFLIXimab
ADALIMumab
CANAKINumab

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Nino OITE (16 decks)

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