Inhalation Anesthetics Definitions Flashcards
Meyer-Overton theory
volatile anesthetics dissolve in cell membranes and result in changes in ion transport through the neuronal cell membrane
protein receptor hypothesis
volatile anesthetics interact with an as yet unidentified receptor in the CNS; the steep dose response curve suggests a critical number of receptors must be occupied
alterations in NT availability hypothesis
volatile anesthetics could interfere with the formation, release, or breakdown of NTs in the CNS; may be part of the mechansism of the Meyer-Overton theory
gas
an agent that exists in its gaseous form at room temp and sea level pressure
vapor
the gaseous state of a substance that is liquid at room temp and sea level pressure
concentration
volume percent of the anesthetic agent in relation to the whole gas mixture
vapor pressure
a measure of an agent’s ability to evaporate; a measure of the tendency for molecules in the liquid state to enter the gaseous (vapor) form
saturated vapor pressure (SVP)
a max concentration of molecules in the vapor state that can exist for a given liquid at a given temp
methoxyflurane SVP
23
halothane SVP
244
isoflurane SVP
240
sevoflurane SVP
170
boiling point
the temperature at which the vapor pressure of the liquid is equal to the atmospheric pressure
solubility coefficient
the extent to which a gas will dissolve in a given solvent
partition coefficient (PC)
the ratio of the concentration of anesthetic in 2 phases (ex: blood-gas partition coefficient) ; describes the affinity of an anesthetic for one compartment over another after equilibrium has been reached
