Tranexamic Acid

Question 1

Indication

Answer 1

Actual or suspected severe haemorrhage in:

Injured patients triggering local major trauma centre

Patients with time critical injury where significant internal or external haemorrhage is known or suspected

PPH after administration of uterotonic drug and patient continues to bleed

Bleeding due to disorders of obstetric origin

Question 2

Action

Answer 2

Anti fibrinolytic which reduces the breakdown of blood clots

Question 3

Contraindications

Answer 3

Known previous anaphylactic reaction

Bleeding starting more than 3hrs ago

Obvious resolution of haemorrhage

Isolated head injury

PPH before administration of uterotonic drug

Critical interventions required (airway etc)

Question 4

Side effect

Answer 4

Hypersensitivity 
Hypotension
Nausea 
Vomiting 
Diarrhoea 
Arterial or venous embolism at site