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Dermpath > Definitions > Flashcards

Definitions Flashcards

1
Q

acantholysis

A

Loss of cell-cell adhesion

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2
Q

Acanthosis

A

Increase in thickness of epidermis

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3
Q

anaplasia

A

Atypical nuclei (size, shape, staining) and pleomorphism (variation in nuclear characteristics)

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4
Q

Apoptosis

A

“dead red” keratinocytes with pyknotic nuclei

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5
Q

arborizing

A

branching (rete; vasculature)

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6
Q

asteroid body

A
  • Collections of pink material in sporotrichosis
  • Star-shaped intracytoplasmic inclusions in giant cells of granulomatous processes (sarcoid)
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7
Q

Atrophy

A

decrease in epidermal thickness

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8
Q

Ballooning degeneration

A

Destruction of epidermis by dissolution of cell attachments and intracellular edema (HSV)

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9
Q

Caterpillar body

A

Degenerated type IV collagen –> Pale pink linear BM material within epidermis (ex: PCT)

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10
Q

Civatte/colloid bodies

A

Pink, globular remnants of keratinocytes

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11
Q

Collagen entrapment

A

Collagen fibers surrounded by histiocytes/spindle cells (ex: dermatofibroma)

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12
Q

Cornoid lamellae

A

Parakeratosis in a column above hypogranulosis and pink dyskeratotic keratinocytes at base (ex: porokeratosis)

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13
Q

Corps ronds

A

rounded nucleus with halo of pink dyskeratotic cytoplasm (ex: Darier)

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14
Q

Grains

A

dark blue flattened nucleus surrounded by minimal cytoplasm (ex: Darier’s)

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15
Q

Dyskeratosis

A

abnormal, individual-cell keratinization

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16
Q

Cowdry / Lipschutz body

A

Pink intranuclear inclusions - Cowdry A: herpesvirus - Cowdry B: adenovirus, poliovirus

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17
Q

Crust

A

Serum/fluid with inflammatory cells/debris in stratum corneum

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18
Q

Donovan body

A

Intracytoplasmic collections of bacteria seen in granuloma inguinale

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19
Q

Dutcher body

A

Intracytoplasmic pink masses of immunoglobulin that invaginate into the nucleus of plasma cells, making them appear intranuclear

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20
Q

Effacement

A

Loss of normal rete pattern

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21
Q

Eosinophilic spongiosis

A

Spongiosis with eosinophils in the epidermis

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22
Q

psoriasiform

A

regular acanthosis

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23
Q

pseudoepitheliomatous hyperplasia

A

irregular acanthosis

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24
Q

Epidermolytic hyperkeratosis

A

disruption of cell membranes –> coarse, irregular hypergranulosis

  • Keratin 1 and 10 mutations
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25
Q

epidermotropism

A

lymphs in epidermis w/NO spongiosis (MF only)

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26
Q

erosion

A

partial thickness loss of epidermis

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27
Q

exocytosis

A

lymphs in epidermis + spongiosis (spong derm)

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28
Q

festooning

A

undulating patterin of papillary dermis (i.e. PCT)

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29
Q

flame figure

A

collagen encrusted with major basic protein from eos (i.e. Wells synd)

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30
Q

foam cell

A

histiocyte filled with lipids

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31
Q

follicular mucinosis

A

pools of mucin alter hair sheath anatomy

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32
Q

granulomatous

A

composed of granulomas (discrete collections of histiocytes)

33
Q

grenz zone

A

uninvolved area of dermis, either beneath epidermis or adjacent to hair follicle

34
Q

Guarnieri body

A

eosinophilic inclusions (smallpox)

35
Q

Henderson-Paterson body

A

oval, pink, intracytoplasmic inclusions (molluscum)

36
Q

hyper-/hypogranulosis

A

increased or decreased granular layer

37
Q

hyper-/hypopigmentation

A

increased or decreased melanin pigment

38
Q

interface

A

related to D-E junction

39
Q

Kamino body

A

dull pink BM material within epidermis (spitz nevus)

40
Q

karyorrhexis

A

fragmentation of neutrophils (leukocytoclasia(

41
Q

koilocytes

A

keratinocytes with clear cytoplasm and shrunken (pyknotic) nuclei

42
Q

Leishman-Donovan body

A

intracytoplasmic collections of amastigotes (leishmaniasis)

43
Q

lentiginous epidermal hyperplasia

A

elongated, bulbous rete ridges

44
Q

lentiginous melanocytic growth pattern

A

proliferation predominantly along D-E junction

45
Q

leukocytoclasia

A

fragmentation of neutrophils (karyorrhexis)

46
Q

lichenoid dermatitis

A

interface dermatitis with destruction of basal layer + Civatte bodies

47
Q

lichenoid infiltrate

A

bandlike infiltrate, usually of lymphs, at D-E junction

48
Q

Medlar body

A

round brown structure resembling overlapping copper pennies (chromomycosis)

49
Q

metachromasia

A

property of staining a different color than stain itself (i.e. mast cell granules stain purple with methylene blue)

50
Q

Michaelis-Gutman body

A

intra- and extracellular calcified, concentric circular structures (malakoplakia)

51
Q

Munro microabscess

A

collection of neuts in stratum corneum (psoriasis)

52
Q

necrobiosis

A

pale-staining, smudged, necrotic collagen

53
Q

Negri body

A

intraneuronal inclusions (rabies)

54
Q

Orthokeratosis

A

stratum corneum without retained nuclei

55
Q

pagetoid cells

A

large cells w/abundant cytoplasm within epidermis

56
Q

pagetoid scatter

A

atypical cells scattered throughout epidermis

57
Q

palisading

A

picket fence-like arrangement of cells at periphery

58
Q

papillary mesenchymal body

A

structure resembling whorl of plump mesenchymal cells normally found in hair papilla (trichoblastoma, trichoep)

59
Q

papillomatosis

A

exophytic, finger-like projections

60
Q

parakeratosis

A

stratum corneum with retained nuclei

61
Q

pigment incontinence

A

melanin within dermal macrophages and free within the dermis

62
Q

pleomorphism

A

variation in nuclear size/shape

63
Q

psammoma body

A

extracellular, laminated, calcified structures (meningioma, papillary thyroid carcinoma, ovarian carcinoma)

64
Q

pseudoepitheliomatous hyperplasia

A

prominent acanthosis of adnexal epithelium and epidermis; often assoc w/trapping of elastic fibers - mimics SCC

65
Q

pseudohorn cyst

A

keratin-filled cystic structure caused by cutting through invaginations of stratum corneum (connects to surface)

66
Q

reticular degeneration

A

epidermal destruction with residual net-like cell membranes

67
Q

reticulated

A

net-like network of interconnecting strands

68
Q

Russell body

A

pink, intracytoplasmic collections of immunoglobulin in plasma cells (rhinoscleroma)

69
Q

Schaumann body

A

laminated, calcified structure (sarcoidosis)

70
Q

shadow cells

A

cells w/barely visible outlines of nuclei (pilomatricoma)

71
Q

spongiform pustule of Kogoj

A

neuts in stratum spinosum, assoc w/spongiosis at periphery (psoriasis)

72
Q

spongiosis

A

intercellular edema in epidermis with stretching of cell-cell junctions

73
Q

squamatization

A

loss of cuboidal/columnar basal cells; deepest layer replaced bu polyhedral, pink, squamous cells

74
Q

squamous eddies

A

circular whorls of squamous cells

75
Q

storifom

A

“cartwheel” or loosely-whorled pattern

76
Q

vacuolar change

A

formation of clear spaces w/i basal layer

77
Q

verocay body

A

structure composed of two nuclear palisades enclosing pink cytoplasmic processes (schwannoma)

78
Q

villus

A

papillary dermis covered by layer of epidermal cells, projecting into a cavity

Dermpath (4 decks)

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