Projestin Injection

Question 1

Therapeutic Class

Answer 1

Hormone

Question 2

Examples

Answer 2

: medroxyprogesterone (Depo Provera, Depo-SubQ-Provera, Provera)

Question 3

Mechanism of Action

Answer 3

inhibits effect of estrogen on uterus

Question 4

Actions and Uses

Answer 4

Contraception, dysfunctional uterine bleeding, endometriosis
Synthetic progestin with prolonged duration of action. Primary target tissue is endometrium.
Inhibits effect of estrogen on uterus
In dysfunction bleeding, restores normal hormonal balance.

Question 5

Adverse Effects

Answer 5

Breakthrough bleeding, breast tenderness, weight gain, depression, hypertension, nausea/vomiting, dysmenorrhea

Question 6

Black Box Warning

Answer 6

Risk for thromboembolic disease, stroke, DVT, MI, pulmonary emboli & invasive breast cancer. Women 65 & > risk of dementia.
Significant risk for loss of bone mineral density

Question 7

Contraindications

Answer 7

Carcinoma of the breast, history of thromboembolic disease. Used in caution with history of depression

Question 8

Interactions

Answer 8

Decreased effects with Barbiturates, rifampin, topiramate, St. John’s wort

Question 9

Preg Cat

Answer 9

X