2.5 Phagocytic cells (Recognition + Response)

Question 1

Pagocytes

Answer 1

-> Neutrophil, Eosinophil, Basophil, Monocyte, Macrophage

Function:

• > General foreign specificity
• > Acute inflammatory response
• > Most prevalent leukocytes
• > Short-lived (hours to days)
• > Huge numbers

Question 2

Phagocytosis - Mechanism

Answer 2

Neutrophils engulf + killthe microbes to which they bind

Bacterial fMet-Leu-Phe peptides activate Rac2 + bacterial are taken up into phagosomes

Phagosomes fuse with primary + secondary granules. Rac2 induces assembly of a functional NADPH oxidase in phagolysosome membrane -> generation of O2. Acidification as a result of ion influx releases granule proteases from granula matrix