atypicals

Question 1

clozapine side effects

Answer 1

agranulocytosis, tachycardia, hypersalivation, myocarditis, seizures

(clozaril)

Question 2

risperidone side effects

Answer 2

orthostatic hypotension, increased prolactin, reflex tachycardia

(risperdal, risperdal consta)

Question 3

quetiapine

Answer 3

sedation, ortho hypotension

seroquel

Question 4

olanzapine

Answer 4

weight gain, dyslipidemia, sedation

zyprexa

Question 5

ziprasidone

Answer 5

qtc prolongation, take with food

geodon

Question 6

aripiprazole

Answer 6

partial d2 agonism
more activating than sedating
less weight gain

(abilify, abilify maintena)

Question 7

paliperidone

Answer 7

from risperidone

invega, invega susteina

Question 8

lurasidone

Answer 8

for bipolar depression, take with food

latuda

Question 9

long-acting (1st and 2nd gen) 4

Answer 9

haloperidol+fluphenazine (deconate)
abilify maintena-aripripazole
risperol consta-riseridone
invega sustaina-paliperidone

Question 10

more sedating 2

Answer 10

clozapine + quetiapine

Question 11

more orthostatic hypotension 2

Answer 11

risperidone + quetiapine

Question 12

can help with tourettes

Answer 12

risperidone

Question 13

other ttx by atypicals besides psychosis

Answer 13

ttx resistant depression, ocd (with ssri)

Question 14

drug classes for mood stabilization (3)

Answer 14

atypicals, lithium, anticonvulsants

Question 15

role of mood stabilizers (3)

Answer 15

1. acute mania, maintenance,
2. augmentation of antidepressants for major depressive disorder, potentiation of antipsychotics in schizo.,
3. treat aggression and impulsivity, enhance abstience in alcoholism

Question 16

lithium uses (4)

Answer 16

acute mania, prophylaxis of manic and depressive episodes of bipolar + schizoaffective

cyclothymic, unipolar depression

Question 17

lithium lab tests

Answer 17

lithium, creatinine, thyroid, cbc, chem, pregnancy, ecg

Question 18

lithium side effects

Answer 18

gi disturbances, ecg changes, sedation, weight gain, benign leukocytosis

tremors, convulsion, mental status change, delurium, coma, death

ebstein’s anomoly

Question 19

factors increasing lithium levels

Answer 19

nsaids, diuretics (HCTZ), aspirin

dehydration
impaired renal function
sweating -salt loss, salt deprivation

Question 20

valproic acid moa

Answer 20

block na channels
increase GABA concn

monitor cbc, lft

Question 21

valproic acid use

Answer 21

acute mania, rapid cycling, mania w/mixed features

Question 22

lamotrigine moa

Answer 22

block na channels that modulate glutamate + aspartate

Question 23

lamotrigine use

Answer 23

bipolar DEPRESSION

Question 24

lamotrigine side effects

Answer 24

sjs at beginning (so low dose and gradually higher)

headache, dizziness, sedation, ataxia

Question 25

valproate lamotrigine relationship

Answer 25

valproate increases lamotrigine

lamotrigine decreases valproate

Question 26

lithium vs carbamazepine

Answer 26

lithium-benign leukocytosis (helpful in clozapine)
vs
carbamazepine-benign leukopenia + aplasic anemia

Question 27

carbamazepine

Answer 27

block Na channels

Question 28

carbamazepine use

Answer 28

acute mania + rapid cycling but not depressive

Question 29

carbamazepine side effects

Answer 29

sedation, confusion, ataxia, gi, benign leukopenia, aplasic anemia, hepatitis, nystagmus, motor restlessness, tremor, twitching

siadh, hyponatremia, sjs, rash

Question 30

carbamazepine monitoring

Answer 30

works 5-7d
monitor levels induction, 3w,6w,9w autometab by p450
cbc, lft,