Drugs in pharmacology Flashcards
How do drugs produce their effect when binding to receptors
Agonism
How do drugs block effects by binding to receptors
Antagonism
Desensitisation
How to we study ion channels
By patch clamp technique
What are the types of agonist
- full agonist
- partial agonist
- neutral agonist
- inverse agonist
What is a benzodiazepine receptor
Ligand gated chloride ion channel
Give an example of benzodiazepine receptor
GABAa receptor
How do allosteric agonist produce an effect to GABAa receptors
Allosteric agonist binds to the receptor to increase the affinity of GABA this increases the channel opening
Agonist of benzodiazepine receptors
- diazepam
- lorazepam
Antagonist of benzodiazepine receptors
Flumanzil
Inverse agonist of benzodiazepine receptor
Beta carbolines
What is a glutamate-gated chloride receptors
A common channel in the nervous system which glutamate (neurotransmitter) binds to
Name an allosteric agonist of glutamate- gated chloride receptor
Invermectin
What are the 5 types of antagonist
- competitive
- irreversible
- allosteric
- channel blockers
- physiological
3 examples of competitive antagonist with their receptor names
- atropine to muscarinic receptors
- propanalol to beta adrenoceptors
- slidenafil to PDE5
Example of an irreversible antagonist with its receptor name
Phenoxybenzamine at alpha adrenoceptors
