JVD 2018 Malignant Transformation of a Canine Papillomavirus Type 1-Induced Persistent Oral Papilloma Legendre et al

Question 1

What are the three types of papillomabirus which dogs carry?

Answer 1

Taupapillomavirus, Chipapillomavirus, and Lambdapapilloma- virus.

Question 2

What is the average age of incidence of CPV-1?

Answer 2

2.3 years

Question 3

What are the suggested causes for non regressing papillomavirus infections?

Answer 3

infection by multiple PV types

cellular immunity defects

humoral immunosuppression

concurrent systemic diseases

Question 4

What treatments are recommended for non regressing infections?

Answer 4

A multimodal approach is recommended involving:

surgery:electrocautery, scalpel, lasers, or cryo- surgery vaccines: documented but no controlled studies immunotherapy:azithromycin, interferon ⍺-2b, and P acne.

Question 5

Which two subtypes have the potential to induce OSCC formation?

Answer 5

CPV-1 & CPV-17

Question 6

With oral CPV-1 what percentage of oral lesions resolve within 2-4 weeks

Answer 6

95%

Question 7

What are the six steps in the cycle of the oral papilloma virus?

Answer 7

Aquisition

Infection

Multiplication

Viral expression

Viral Assembly

Release

Question 8

What are some of the cellular immunity defects associated with nonregressive infection?

Answer 8

Defects of keratinocytes, dendritic cells, and Langerhans cells.

Question 9

What did the presence of CPV-1 DNA in the OSCC suggest?

Answer 9

That the virus might have played a role in the emergence of the OSCC