Enzyme inhibitors/inducers

Question 1

↑ enzyme activity + ↓ drug concentration?
(inducers)

“PC BRAS”

Answer 1

PC BRAS

P henytoin
C arbamazepine
B arbiturates
R ifampicin
A lcohol (chronic)
S ulphonylureas

Question 2

↓ enzyme activity + ↑ drug concentration?
(inhibitors)

“AODEVICES”

Answer 2

AODEVICES

A llopurinol
O meprazole
D isulfiram
E rythromycin
V alproate
I soniazid
C iprofloxacin
E thanol (acute)
S ulphonamides

Question 3

P450 inhibitors?

“SICKFACES.COM-group”

Answer 3

Sodium valproate
Isoniazid
Cimetidine
Ketonazole
Fluconazole
Alcohol (binge)
Chloramphenicol
Erythromycin
Sulfonamides (i - inhibitor)
.
Ciprofloxacin
OMEPRAZOLE
METRONIDAZOLE
-
Grapefruit juice

Question 4

P450 inducers?

CRAP-GPS

Answer 4

CRAP-GPS induces me to madness

Carbamazepines
Rifampicin
Alcohol (chronic)
Phenytoin
Griseofulvin
Sulphonylurea (u - inducer)