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MBB343 > single pass receptors > Flashcards

single pass receptors Flashcards

1
Q

What type of ligand do all single pass receptors respond to?

A

peptide ligands

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2
Q

What is the 2nd messenger to guanylate cyclase receptors?

A

cGMP

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3
Q

What is an example of a membrane bound guanylate cyclase receptor?

A

Atrial Naturetic Receptor

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4
Q

What are the effects of ANP (Atrial Naturetic Peptide) binding to ANR (Atrial Naturetic Receptor)?

A

Activated receptor dimerises and has GCase activity.
Causes vascular smooth muscle to relax.
Kidneys secrete more water and sodium
Decreased venous return to the heart

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5
Q

What other signalling pathway does ANP signalling have the same downstream affects of?

A

Nitric Oxide signalling

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6
Q

Why is transforming growth factor beta normally released?

A

to inhibit cell proliferation

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7
Q

What type of receptor is the TGFbeta receptor?

A

Type II/Type 1 homodimer

Receptor has intracellular kinase activity

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8
Q

What is the second messenger of TGFbeta singaling?

A

SMAD transcription factors

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9
Q

What does phosphorylation of a SMAD cause to happen?

A

Unmasks the NLS

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MBB343 (3 decks)

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