Colitis, Pancreas & Liver

Question 1

What human anti-inflammatories work well for chronic colitis?

Answer 1

5-amino-salicylic acid (risk in cats)
- symptomatic therapy
sulfasalazine
- anti-lipooxygenase, decrease IL-1, decrease PGE synthesis, and oxygen free radicals

Question 2

What antimicrobials can be used for chronic colitis ? (although its hit and miss)

Answer 2

metronidazole (giardia, anaerobes)
Tylosin (macrolide)
- anti-inflammatory

Question 3

How are glucocorticoids helpful with colitis? which ones are used?

Answer 3

Prednisone/prednisolone

Budesonide (human crohn’s)

Question 4

What other immunosupressive drugs can be used for chronic colitis?

Answer 4

azathioprine, chorambucil, cyclosporine

Question 5

What drug can be used for exocrine pancreatic insufficiency?

Answer 5

Pacrelipase (Pank-aid)
- supplment exocrine enzymes (lipase, amylase, proteases
how to use: on dogs food

Question 6

What is significant about Pank-Aid enzymes to prevent denaturing in stomach?

Answer 6

coated
mix with food to start digestion before eating
use with H2 receptor to better reach duodenum

Question 7

Although no considerable effective therapy for hepatitis what can be used?

Answer 7

Vit E and milk thistle extract (chronic)
glucocorticoids
Cholchicine
Cu chelators
penicillamine
- can cause vomiting
Trientine (safer than penicillamine)
Zinc (blocks intestinal absorption of copper

Question 8

What drug is obtained from an alberta animal that can be used to treat hepatitis?

Answer 8

Ursodiol (bile acid from bears)

• impairs cholesterol uptake
• reduced hepato toxic effect of bile acid
• aid in clearing of cholesterol gallstones
• limited adverse effects

Question 9

What nutritional supplement can be used to treat hepatitis?

Answer 9

SAMe

• increases hepatic concentrations of glutathione
• safe for acute or chronic
• feed greatly reduced F