Midterm 1 (Lab) Flashcards
What are the 2 types of error and their definitions? What do they affect?
- Random
- Happens by chance
- Affects precision - Systematic
- Happens regularly due to design
- Affects internal validity; cannot be fixed, only prevented
How does random error occur?
- Respondent memory lapse (client is unintentionally hiding things)
- Incorrect estimation of portion sizes
- Coding errors (can happen when converting portion sizes or inputting food items into nutrient analysis programs)
- Mistakes in handling of mixed dishes
- Inaccurate food composition values
How does systematic error occur?
- Non-response bias: sample is not representative of the population of interest
- Respondent bias: systematic underreporting or overreporting
• Client is intentionally changing their reports due to social desirability - Interviewer bias: probing for information, omitting certain questions, recording responses incorrectly
- Omitting supplement use
What are methods to reduce error?
- For random error, increase # of days in dietary recall
- Good equipment
- Calibration checks
- Training
- Protocols
- Correct equations and assumptions
- Use multiple indices together to provide more accurate measure
What is the sensitivity of a measure?
- Tool is able to capture anyone who is ill or malnourished or at risk
- 100% sensitive ⟶ no malnourished person classified as “well”
What is the specificity of a measure?
- Tool identifies those who are well-nourished
- 100% specific ⟶ no well-nourished people classified as “ill”
What is anthropometry?
Measurements of variations of the physical dimensions (growth) and the composition of the human body
What are the benefits of anthropometry?
- Simple
- Safe and non-invasive
- Provide information on long-term nutritional status and challenges
- Can identify malnutrition
What are the cons of anthropometry?
- Insensitive (not able to detect short-term changes)
- Cannot distinguish nutrient deficiencies
What are the indices for anthropometry?
- Single raw measurement (eg. weight)
- Combination of raw measurements (eg. BMI)
- Combinations used in prediction equations (eg. % body fat from skinfold thicknesses)
What types of anthropometric measurements might you take for a child?
Head circumference, weight, length (<24 months as they cannot stand), height (>24 months), knee height, lower leg length
What do growth charts indicate?
- Compare weight for height for age with population to assess growth
- Can indicate stunting (long-term malnutrition) and wasting (short-term malnutrition)
What types of anthropometric measurements might you take for an adult?
- Weight, height, knee height, arm span, elbow breadth, waist circumference, hip circumference
- Elbow breadth estimates frame size (related to body fat and FFM)
- Lower leg span, mid-arm span, and knee height estimates height
What is the relevance of measuring waist circumference?
- Better correlation to abdominal fat (related to metabolic disturbances) than waist-to-hip ratio (WHR)
- Cut-off value for WC varies by gender and race
- Done for BMIs between 18.5-34.9 to identify risk
- For BMI of 35+, WC doesn’t provide additional information (high risk of disease)
What are the 3 methods of measuring waist circumference
- WHO Waist Circumference Measurement Technique
- Middle of lower page of rib cage and highest part of hip bone - NIH Waist Circumference Measurement Technique
- Highest part of hip bone - Umbilicus Waist Circumference Measurement
- Belly-button
Why would you take weight measurements?
- Identify changes over time (to see if patient is responding to intervention)
- Use weight-height ratios to plug into equations (Ponderal Index, BMI or Quetelet’s Index)
How do you take height measurements?
- If the individual can stand, use a stadiometer
- Take a full breath in to reduce slouching
- Head should be in the Frankfurt Plane (having head straight and parallel to the earth)
- Heels should be touching the wall
- Arms relaxed at the sides
- Height should be read to the nearest inch or 0.5 cm
What are the 3 body composition models?
2 COMPARTMENTS:
- Fat mass (essential + storage lipids)
• More sensitive than muscle to acute malnutrition
- Fat free mass ⟶ body mass - fat mass (muscle, bone, connective tissue)
• Lean body mass is FFM + essential fat in body
3 COMPARTMENTS:
- Fat mass
- FFM
- Mineral mass (separates bone from FFM)
4 COMPARTMENTS:
- Fat mass
- Water
- Protein
- Mineral mass
What measurement do you take to assess muscle? What are the limitations of this method?
- Mid-arm muscle circumference (MAMC) measures total body muscle mass (index of protein stores)
- Most common and easy
- May not correlate with muscle in entire body, assume that bone and fat mass are negligible, not sensitive to small changes
Where are skinfold measurements taken and what do they tell you? What are the limitations?
- Done at triceps, bicepts, subscapular, suprailliac
- Measurements are plugged into equations for body fat
- May be inaccurate depending on how fat is distributed throughout the body, poor calibration, measurements may vary depending on training of person
What is BIA and what does it assess?
BIOELECTRICAL IMPEDANCE ANALYSIS:
- Safe and cheap machine found in all clinical settings
- Sends electrical current through body, which passes through water (high conductivity)
- Fat has low conductivity
- Machine converts water content to FFM
- Based on assumption that 73% of FFM is water
What are the benefits of biochemical assessment?
- Very sensitive (small changes, short-term)
- Highly specific (measures only substance of interest)
What are the components of blood?
- Whole blood (eg. hemoglobin, hematocrit, glucose)
- Serum (supernatant from coagulated blood)
- Will not contain coagulation proteins - Plasma (supernatant from anti-coagulated blood)
- Does contain coagulation factors
What is the most common deficiency in the world and its stages?
Iron deficiency
- Fe depletion ⟶ low ferritin
- Fe deficient erythropoiesis ⟶ less production of RBC in bone marrow
- Fe deficiency anemia ⟶ less Hb
Discuss hemoglobin to assess Fe status.
- Low sensitivity (only detects 3rd stage anemia)
- Poor specificity (iron, folate, vitamin B12, copper, and protein can decrease hemoglobin)
• Malaria
• Pregnancy (blood volume increases to dilute Hb) ⟶ cut-offs should be lower
• Smoking decreases O2 in RBC which will increase production of Hb to compensate
• Other factors can affect such as race and altitute
What does clinical assessment consist of?
- Review of medical history
- Family history
- Signs (objective) and symptoms (subjective; patient’s feeling)
- Use of medications (past and current)
- Previous surgeries, medical procedures
What are the types of dietary assessment and where are they used?
- Diet History (clinical practice)
- 24-Hr Recall (research, sometimes in clinical practice)
- Food Record (research, sometimes in clinical practice)
- Food Frequency Questionnaire (FFQs) (research, sometimes in clinical practice)
Discuss the method and pros/cons of diet history.
- Asks about a typical day to get a general idea of intake
- Doesn’t require literacy (interview process), doesn’t require patient to be eating regular diet, quick, easy
- Based on client perception/memory, only gives rough estimate, not standardized method that can be used for research
Discuss the method and pros/cons of 24-hour recalls.
- Asking patient to remember what they ate over the past day
- Quick, easy, literacy not required, doesn’t affect dietary intake of client
- Relies on memory, estimated serving sizes, one day may not be representative of usual intake, does not account for seasonal variation
- Better to do multiple 24-hour recalls
Discuss the method and pros/cons of food records.
- Asking patients to write down everything they eat for a few days
- Best method of dietary assessment
- Does not rely on memory, accurate data, weighed or estimated food for accurate portion sizes
- May affect dietary intake of client, burdensome, literacy required, does not account for seasonal variation
Discuss the method and pros/cons of food frequency questionnaires.
- Ask patients to indicate how frequent they consume list of food items
- Better at assessing general patterns than nutrient and kcal intakes
- May assess the full diet or only nutrients of interest (eg. calcium-rich products)
- May be quick, does not affect the dietary intake, may account for seasonal variation
- May be time-consuming, literacy required, relies on perception/memory, cognitively difficult, FFQ must be suitable for client’s culture