PMR Flashcards
1
Q
What is the diagnostic criteria?
A
Mandatory
Age >50
Aching both shoulders
Abnormal CRP and ESR
Extra Morning stiffness >45mins Reduced hip ROM Negative RF and CCP Absence of peripheral synovitis Utrasonographic findings
2
Q
What are the clinical features?
A
Aching and stiffness around neck, shoulders, and lumbar region
Muscle strength normal however testing limited by pain
Can be associated with depression, fatigue, and wt loss
3
Q
Which cytokine is central?
A
IL-6
4
Q
Which imaging modality is useful?
A
PET
5
Q
What is the PMR-activity score made up of?
A
Morning stiffness, elevated of UL, global physician ax, pain intensity, and CRP
Less <7 = low disease activity
6
Q
What does of pred should you use?
A
Low dose - 15mg/day 4 weeks
then reduced by 2.5mg every two weeks
Then 1mg each month to wean
- if relapse - go back to the previous effective dose
7
Q
Which other agents have been trialle?
A
Methotrexate
Etanercept (modest benefit only)
