Pathophysiology Flashcards
1
Q
MND (ALS)
A
Degeneration of upper and motor neurones in spinal cord + cranial nerve motor nuclei + cortex
- Exitotoxicity of neurotransmitter induced by glutamate disrupting calcium homeostasis
2
Q
2 pathologic hallmarks of Alzheimer’s disease
A
- Extracellular beta amyloid deposits (senile plaques)
- Intracellular neurofibrillarly tangles (Paired helical filaments)
3
Q
Alzheimer’s disease pathophysiology (5)
A
- Betaamyloid deposition
- Neurofibrillary tangles
- Loss of synapes and neurons
- Gross atrophy of brain areas
- Starts at medial temporal lobe
4
Q
What lobe does Alzheimer’s disease start at?
A
Medial temporal lobe
5
Q
What areas of the brain are most vulnerable in Alzheimer’s? (4)
A
- Hippocampus
- Amygala
- Temporal neuocortex
- Subcortical nuclei
6
Q
What is uncontrollable laughter and crying a sign of in MND? (2)
A
Psuedobulbar affect - UMNL sign
Affected corticobulbar tract
