Anti-Epileptic Drugs Flashcards
1
Q
What epilepsy drugs target voltage gated Ca2+ channels to inhibit them?
A
Pregabalin
Gabapentin
Ethosuximide
2
Q
What epilepsy drugs target voltage gated-sodium channels to inhibit them?
A
Carbamazepine, phenytoin, lamotrigine
3
Q
What is the mode of action of sodium valproate?
A
Blocks sodium channels
Increases GABA concentration
4
Q
Side effects of carbamazepine
A
Diplopia Ataxia Blood dyscrasias Teratogenicity Hyponatraemia
5
Q
Side effects of phenytoin
A
Nystagmus Diplopia Ataxia Sedation Gingival hyperplasia Hirsutism Peripheral neuropathy Megaloblastic anaemia Teratogenicity
6
Q
Lamotrigine side effects
A
Rash
Steven-Johnson syndrome
7
Q
Ethosuximide side effects
A
GI upset Fatigue Headache Urticaria Steven-johnson syndrome
8
Q
Sodium valproate side effects
A
GI upset Liver failure Neural tube defects Tremor Weight gain
9
Q
What anti-convulsants are hepatic enzyme inducers?
A
Carbamazepine Oxcarbazepine Phenobarbitol Phenytoin Primidone Topiramate
10
Q
What is the advice for women on enzyme inducing anti-convulsants?
A
Can alter efficacy of the COCP Shouldn't use POP Depot progesterone needs more frequent dosing Progesterone implants not effective Morning after pill dose needs increased
